A narrative review of hydrogen-oxygen mixture for medical purpose and the inhaler thereof

Abstract

Recent development regarding mixture of H 2 (concentration of ~66%) with O 2 (concentration of ~34%) for medical purpose, such as treatment of coronavirus disease-19 (COVID-19) patients, is introduced. Furthermore, the design principles of a hydrogen inhaler which generates mixture of hydrogen (~66%) with oxygen (~34%) for medical purpose are proposed. With the installation of the liquid blocking module and flame arresters, the air pathway of the hydrogen inhaler is divided by multiple isolation zones to prevent any unexpected explosion propagating from one zone to the other. An integrated filtering/cycling module is utilized to purify the impurity, and cool down the temperature of the electrolytic module to reduce the risk of the explosion. Moreover, a nebulizer is provided to selectively atomize the water into vapor which is then mixed with the filtered hydrogen-oxygen mix gas, such that the static electricity of a substance hardly occurs to reduce the risk of the explosion. Furthermore, hydrogen concentration detector is installed to reduce the risk of hydrogen leakage. Result shows that the hydrogen inhaler implementing the aforesaid design rules could effectively inhibit the explosion, even ignition at the outset of the hydrogen inhaler which outputs hydrogen-oxygen gas (approximately 66% hydrogen: 34% oxygen).

Early Hydrogen–Oxygen Gas Mixture Inhalation in Patients with Aneurysmal Subarachnoid Hemorrhage (HOMA): study protocol for a randomized controlled trial

“…2 ). A comprehensive review has furnished in-depth insights into the device’s underlying principles, safety features, and its method of application within the trial [ 25 ]. In addition to the device’s specialized design, stringent safety measures will be implemented, including the conduction of the study within a well-ventilated environment and the utilization of an ambient hydrogen concentration monitor to ensure that the hydrogen concentration in the surroundings remains below 4%.…”

Current views on the functional role of hydrogen and its kinetics in the human body

“…Comparison of the areas under the hydrogen concentration curves after ingestion of hydrogen-rich water (peak on the left) and after fermentation of carbohydrates from milk indicates the ability of the intestinal microbiota to generate large amounts of hydrogen over a long period of time [47] Концентрация водорода в выдыхаемом воздухе, ррм ных. Во-первых, подтверждена безопасность ингаляционного использования водорода в концентрации 2-4 % [61], а также более высоких концентраций, в частности у больных COVID-19, при ингаляции воздушной смеси, содержащей 66 % водорода и 34 % кислорода [62,63]. Во-вторых, подтверждены кардио-и нейропротективные эффекты молекулярного водорода у пациентов, что было связано с его антиоксидантными свойствами [64].…”