A nationwide epidemiological survey of chronic hypersensitivity pneumonitis in Japan

Okamoto, Tsukasa; Miyazaki, Yasunari; Ogura, Takashi; Chida, Kingo; Kohno, Nobuoki; Kohno, Shigeru; Taniguchi, Hiroyuki; Akagawa, Shinobu; Mochizuki, Yoshiro; Yamauchi, Kohei; Takahashi, Hiroki; Johkoh, Takeshi; Homma, Sakae; Kishi, Kazuma; Ikushima, Soichiro; Konno, Satoshi; Mishima, Michiaki; Ohta, Ken; Nishioka, Yasuhiko; Yoshimura, Nobuyuki; Munakata, Mitsuru; Watanabe, Kentaro; Miyashita, Yoshihiro; Inase, Naohiko

doi:10.1016/j.resinv.2013.03.004

Cited by 67 publications

(41 citation statements)

References 27 publications

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“…Despite the bias of FHP frequency, the number of FHP cases at the study inception (38/93 or 41%) is comparable to reports from more recent studies of patients evaluated at tertiary referral centers, ranging from 11 to 57% [3••, 4-7]. Moreover, the frequency of computerized tomography (CT) images of honeycomb changes in chronic HP was reported to be 41% in an ethnically homogenous group (Japanese epidemiological survey) [8].…”

Section: Introductionsupporting

confidence: 71%

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Fibrotic hypersensitivity pneumonitis

Pérez

Brown

2014

Curr Respir Care Rep

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Fibrotic hypersensitivity pneumonitis (FHP) is a specific form of HP defined by chest imaging evidence or pathologic evidence of fibrosis or scarring. Fibrotic HP appears to be irreversible, is often progressive and frequently indistinguishable from other forms of chronic fibrosing interstitial lung diseases (ILD), in particular idiopathic pulmonary fibrosis (IPF). Accurate diagnosis is a challenge given the diverse and often nonspecific clinicoradiologic patterns, heterogenous clinical course, and a frequent lack of a readily recognizable temporal relationship between exposure to an inciting antigen (IA) and symptoms in more than half of the patients. This chapter focuses on the clinical features, diagnostic evaluation and management of FHP.

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Section: Introductionsupporting

confidence: 71%

“…Often, these features may coexist with round glass opacities and sometimes with zones of emphysema. The distribution of these abnormal features is generally in the mid to upper and peripheral lung zones, though a lower zone predominance has been described in 11-43% of cases, making its distinction from UIP/IPF challenging [5,8,21,41].…”

Section: Chest Imagingmentioning

confidence: 99%

Fibrotic hypersensitivity pneumonitis

Pérez

Brown

2014

Curr Respir Care Rep

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“…We adopted the diagnostic criteria for chronic HP established by Yoshizawa with the addition of immunological examinations. Bird-related HP and summer type HP constitute the majority of chronic HP cases induced by known antigens according to a recent epidemiological study in Japan [17]. This prompted us to perform immunological examinations for HP in our ILD patients with suspected HP.…”

Section: Discussionmentioning

confidence: 99%

Antigen avoidance tests for diagnosis of chronic hypersensitivity pneumonitis

Tsutsui

Miyazaki

Okamoto

et al. 2015

Respiratory Investigation

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“…The disease, therefore, is collectively referred to as “bird-related hypersensitivity pneumonitis” (BRHP). BRHP accounted for 134 (60%) of 222 cases of chronic HP in a Japan-wide epidemiological survey from 2000 to 2009 [4]. In a report from Morell et al, meanwhile, 13 of 46 patients diagnosed with idiopathic pulmonary fibrosis (IPF) were afflicted with BRHP [5].…”

Section: Introductionmentioning

confidence: 99%

Protein antigen of bird-related hypersensitivity pneumonitis in pigeon serum and dropping

et al. 2017

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BackgroundAvian antigen is a common cause of hypersensitivity pneumonitis (HP). Inhalation challenge with pigeon serum and pigeon dropping extract (PDE) elicits a hypersensitivity reaction in patients with bird-related hypersensitivity pneumonitis (BRHP), but the antigenic components in these materials have yet to be fully elucidated.MethodPigeon serum, pigeon intestine homogenates, and PDE were immunoblotted with serum samples from 8 patients with BRHP, 2 patients with summer-type HP, 2 patients with humidifier lung, and 3 healthy volunteers. Among the protein spots found in both pigeon serum and PDE, those that reacted with sera from BRHP patients were identified by mass spectrometry. Immunoassays using recombinant protein were performed to confirm the antigenicity of the identified protein. Cytokine production by peripheral blood mononuclear cells (PBMCs) stimulated with recombinant protein was also assessed.ResultsImmunoglobulin lambda-like polypeptide-1 (IGLL-1) was identified from all spots on 2-DE immunoblots of both pigeon serum and PDE. The BRHP patients exhibited higher levels of serum IgG antibody against the recombinant IGLL-1 (rIGLL-1) compared to the control subjects, as well as a stronger PBMCs proliferative response to rIGLL-1. Cytokine production by PBMCs from BRHP patients after rIGLL-1 exposure indicated that the protein could induce Th1 prone immune responses: an increase in TNF-α and an absence of elevated IL-10 production.ConclusionsPigeon IGLL-1 was identified as the BRHP antigen present in both pigeon serum and PDE.Electronic supplementary materialThe online version of this article (doi:10.1186/s12931-017-0555-4) contains supplementary material, which is available to authorized users.

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A nationwide epidemiological survey of chronic hypersensitivity pneumonitis in Japan

Cited by 67 publications

References 27 publications

Fibrotic hypersensitivity pneumonitis

Fibrotic hypersensitivity pneumonitis

Antigen avoidance tests for diagnosis of chronic hypersensitivity pneumonitis

Protein antigen of bird-related hypersensitivity pneumonitis in pigeon serum and dropping

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