2015
DOI: 10.1016/j.ebiom.2015.09.030
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A Nationwide Survey of Hepatitis E Virus Infection and Chronic Hepatitis E in Liver Transplant Recipients in Japan

Abstract: BackgroundRecently, chronic hepatitis E has been increasingly reported in organ transplant recipients in European countries. In Japan, the prevalence of hepatitis E virus (HEV) infection after transplantation remains unclear, so we conducted a nationwide cross-sectional study to clarify the prevalence of chronic HEV infection in Japanese liver transplant recipients.MethodsA total of 1893 liver transplant recipients in 17 university hospitals in Japan were examined for the presence of immunoglobulin G (IgG), Ig… Show more

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Cited by 55 publications
(82 citation statements)
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“…However, the routes of HEV transmission in our individual patients with anti‐HEV IgG positive were not uncovered in this cross‐sectional study. In immunosuppressed patients, HEV is transmitted via both the classical routes, namely fecal and/or oral route as well as the consumption of undercooked meat similarly as the general population, and other modes of transmission via liver graft, renal graft, blood transfusion, and hemodialysis unit as nosocomial infections . Although organ transplant recipients are exposed to various HEV infection routes, no kidney transplant recipients experienced symptomatic hepatitis due to HEV in our cohort.…”
Section: Discussionmentioning
confidence: 86%
See 1 more Smart Citation
“…However, the routes of HEV transmission in our individual patients with anti‐HEV IgG positive were not uncovered in this cross‐sectional study. In immunosuppressed patients, HEV is transmitted via both the classical routes, namely fecal and/or oral route as well as the consumption of undercooked meat similarly as the general population, and other modes of transmission via liver graft, renal graft, blood transfusion, and hemodialysis unit as nosocomial infections . Although organ transplant recipients are exposed to various HEV infection routes, no kidney transplant recipients experienced symptomatic hepatitis due to HEV in our cohort.…”
Section: Discussionmentioning
confidence: 86%
“…Conversely, many cases of HEV infection have been reported from endemic regions such as Toulouse, France. In Japan, we identified a low prevalence of anti‐HEV immunoglobulin (Ig)G (2.9%) and HEV RNA (0.12%) in liver transplant recipients via a national survey . Meanwhile, the status and prognosis of HEV infection in kidney transplant recipients remain unknown.…”
Section: Introductionmentioning
confidence: 99%
“…[9][10][11][12][13][14][15][16][17][18][19][20] It bears characteristics resembling hepatitis E that is indigenous to Europe and the United States, that is, higher clinical attack rates in older rather than young adults, and excess case-fatality rates among elderly men and women but not pregnant women. 1 Although in the west chronic HEV infection also has been found among SOTRs, 2 up to recently 3,30 it is unknown if this phenomenon extends to SOTRs in Asia. Prompted by findings from our first SOTR patient, 21 we have identified seven more SOTRs with hepatitis E (Table 1).…”
Section: Demographic and Clinical Featuresmentioning
confidence: 99%
“…In most symptomatic patients with no underlying conditions, an HEV infection resembles typical acute viral hepatitis and usually resolves spontaneously . However, in immunocompromised patients, HEV can cause chronic infections that last longer than 3 months . An understanding of the viral mutations that arise in patients with an impaired or weakened immune response may yield insights into fundamental viral mutational patterns and biases, as well as the rate of turnover in dominant viral sequence.…”
Section: Introductionmentioning
confidence: 99%