A natural polymer based bioadhesive with self-healing behavior and improved antibacterial properties

Ke, Xiang; Dong, Zhiyun; Tang, Shuxian; Chu, Wenlin; Zheng, Xiaoran; Li, Zhen; Chen, Xingyu; Ding, Chunmei; Luo, Jun; Li, Jianshu

doi:10.1039/d0bm00624f

Cited by 61 publications

(44 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…using tannic acid. [ 90,96 ] They prepared the bioadhesive with self‐healing properties by mixing the silk fibroin proteins and TA with the assistance of a twin‐barreled syringe. Tests on porcine skin tissue indicated neither detachment nor cracking in any processed samples, even after being immersed, distorted, or flushed in water.…”

Section: Materials Properties and Multifunctions Of Biopolymer‐based ...mentioning

confidence: 99%

Emerging Biopolymer‐Based Bioadhesives

Martinez

et al. 2021

Macromolecular Bioscience

View full text Add to dashboard Cite

Bioadhesives have been widely used in healthcare and biomedical applications due to their ease‐of‐operation for wound closure and repair compared to conventional suturing and stapling. However, several challenges remain for developing ideal bioadhesives, such as unsatisfied mechanical properties, non‐tunable biodegradability, and limited biological functions. Considering these concerns, naturally derived biopolymers have been considered good candidates for making bioadhesives owing to their ready availability, facile modification, tunable mechanical properties, and desired biocompatibility and biodegradability. Over the past several years, remarkable progress has been made on biopolymer‐based adhesives, covering topics from novel materials designs and advanced processing to clinical translation. The developed bioadhesives have been applied for diverse applications, including tissue adhesion, hemostasis, antimicrobial, wound repair/tissue regeneration, and skin‐interfaced bioelectronics. Here in this comprehensive review, recent progress on biopolymer‐based bioadhesives is summarized with focuses on clinical translations and multifunctional bioadhesives. Furthermore, challenges and opportunities such as weak adhesion strength at the hydrated state, mechanical mismatch with tissues, and unfavorable immune responses are discussed with an aim to facilitate the future development of high‐performance biopolymer‐based bioadhesives.

show abstract

Section: Materials Properties and Multifunctions Of Biopolymer‐based ...mentioning

confidence: 99%

Emerging Biopolymer‐Based Bioadhesives

Martinez

et al. 2021

Macromolecular Bioscience

View full text Add to dashboard Cite

show abstract

“…Ke et al fabricated a bioadhesive based on TA and a silk fibroin hydrogel embedded with silver nitrate. [65] TA serves as reductant-inducing agent for formation of AgNPs in addtion to adhesion moiety. They demonstrated evenly distributed AgNPs within the hydrogel bioadhesive, and antibacterial activities against Escherichia coli and Staphylococcus aureus in vitro.…”

Section: Antimicrobial Bioadhesivesmentioning

confidence: 99%

“…Antibiotic release Thiolated chitosan with poly(N-isopropyl acrylamide) loaded with ciprofloxacin [62] Poly(lactic-co-glycolic acid) (PLGA), poly(β-amino esters) (PAE), fibroblast growth factor (bFGF), and ceftriaxone sodium (CTX) [63] Hyaluronic acid (HA), dopamine, doxycycline, and reduced graphene oxide (rGO) [64] Introducing metal nanoparticles Silk fibroin (SF), tannic acid (TA), and silver nanoparticles (AgNPs) [65] Introducing cationic functional group Polyethylenimine (PEI) and polydextran aldehyde (PDA) [66] N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride (HTCC) and PDA [67] Incroporating organic acids 10-undecylenic acid (UA), poly (ethylene glycol) (PEG), and L-dopamine [68] Preventing microbial adhesion Carbopol (C), cellulose acetate, and perfluorocarbon liquid [69] Polyurethane (PU), chitosan, polysulfobetaines, and siliconje oil [70] Cell-infiltrative Introducing reversible crosslinks PEG and LAPONITE [70] Dopamine modified PEG (PEGDA) and gelatin microgel [71] Gelatin and β-cyclodextrin (β-CD) [72] Increasing pore size Silica microparticle and PEGDA [73] Electrically conductive…”

Section: Antimicrobialmentioning

confidence: 99%

Rational engineering and applications of functional bioadhesives in biomedical engineering

Park

Kim

Chun

et al. 2021

Biotechnology Journal

View full text Add to dashboard Cite

For the past decades, several bioadhesives have been developed to replace conventional wound closure medical tools such as sutures, staples, and clips. The bioadhesives are easy to use and can minimize tissue damage. They are designed to provide strong adhesion with stable mechanical support on tissue surfaces. However, this monofunctionality of the bioadhesives hinders their practical applications. In particular, a bioadhesive can lose its intended function under harsh tissue environments or delay tissue regeneration during wound healing. Based on several natural and synthetic biomaterials, functional bioadhesives have been developed to overcome the aforementioned limitations. The functional bioadhesives are designed to have specific characteristics such as antimicrobial, cell infiltrative, stimuli-responsive, electrically conductive, and self-healing to ensure stability under harsh tissue conditions, facilitate tissue regeneration, and effectively monitor biosignals. Herein, we thoroughly review the functional bioadhesives from their fundamental background to recent progress with their practical applications for the enhancement of tissue healing and effective biosignal sensing.Furthermore, the future perspectives on the applications of functional bioadhesives and current challenges in their commercialization are also discussed.

show abstract

“…16–20 It has a large number of phenolic hydroxyl groups that can form strong hydrogen bonds with PAAM, PVA, PEG, DNA and other polymer molecules. 21–27 And its aromatic ring can also construct hydrophobic interaction with macromolecules that have hydrophobic domains. 28–30 Therefore, the introduction of TA into hydrogels is a very promising strategy to toughen materials via building up non-covalent interactions with the polymer backbones and dissipating mechanical energy under deformation.…”

Section: Introductionmentioning

confidence: 99%

The solvent effect modulates the formation of homogeneous polyphenol composite hydrogels with improved transparency and mechanical strength for antibacterial delayed sternal closure films

et al. 2022

View full text Add to dashboard Cite

show abstract

A natural polymer based bioadhesive with self-healing behavior and improved antibacterial properties

Abstract: Bioadhesives are of great interest for tissue/wound closure to reduce surgical time, minimize treatment invasiveness, and prevent body fluid leakage.

Cited by 61 publications

References 50 publications

Emerging Biopolymer‐Based Bioadhesives

Emerging Biopolymer‐Based Bioadhesives

Rational engineering and applications of functional bioadhesives in biomedical engineering

The solvent effect modulates the formation of homogeneous polyphenol composite hydrogels with improved transparency and mechanical strength for antibacterial delayed sternal closure films

Contact Info

Product

Resources

About