A naturally isolated symbiotic bacterium suppresses flavivirus transmission by<i>Aedes</i>mosquitoes

Zhang, Liming; Wang, Daxi; Shi, Peibo; Li, Juzhen; Niu, Jichen; Chen, Jielong; Wang, Gang; Wu, Linjuan; Chen, Lu; Yang, Zhenxing; Li, Susheng; Meng, Jinxin; Ruan, Fangchao; He, Yuwen; Zhao, Hailong; Ren, Zirui; Wang, Yibaina; Liu, Yang; Shi, Xiaolu; Wang, Yunfu; Liu, Qiyong; Li, Junhua; Wang, Penghua; Wang, Jinglin; Zhu, Yibin; Cheng, Gong

doi:10.1126/science.adn9524

Cited by 13 publications

(1 citation statement)

References 72 publications

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“…Consequently, elevated levels of chenodeoxycholic acid (GCDCA and TCDCA) result in the inhibition of TGR5-NF-κB-mediated systemic inflammatory responses, ultimately contributing to the mitigation of the severity and mortality rates associated with SFTS. It is noteworthy that the vector gut microbiota may serve as a potential target for mitigating viral infections [ 172 ]. The current research demonstrates that RVFV or SFTSV infection significantly impacts the primary vectors of microbial diversity, richness, and composition [ 173 , 174 ], variations in microbiota may play a role in the infection and transmission dynamics of phenuiviruses.…”

Section: Gut Microbiota and Platelet In Phenuivirus Infectionmentioning

confidence: 99%

Current insights into human pathogenic phenuiviruses and the host immune system

Zhou,

Jiang,

Liu

et al. 2024

Virulence

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Phenuiviruses are a class of segmented negative-sense single-stranded RNA viruses, typically consisting of three RNA segments that encode four distinct proteins. The emergence of pathogenic phenuivirus strains, such as Rift Valley fever phlebovirus (RVFV) in sub-Saharan Africa, Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) in East and Southeast Asia, and Heartland Virus (HRTV) in the United States has presented considerable challenges to global public health in recent years. The innate immune system plays a crucial role as the initial defense mechanism of the host against invading pathogens. In addition to continued research aimed at elucidating the epidemiological characteristics of phenuivirus, significant advancements have been made in investigating its viral virulence factors (glycoprotein, non-structural protein, and nucleoprotein) and potential host–pathogen interactions. Specifically, efforts have focused on understanding mechanisms of viral immune evasion, viral assembly and egress, and host immune networks involving immune cells, programmed cell death, inflammation, nucleic acid receptors, etc. Furthermore, a plethora of technological advancements, including metagenomics, metabolomics, single-cell transcriptomics, proteomics, gene editing, monoclonal antibodies, and vaccines, have been utilized to further our understanding of phenuivirus pathogenesis and host immune responses. Hence, this review aims to provide a comprehensive overview of the current understanding of the mechanisms of host recognition, viral immune evasion, and potential therapeutic approaches during human pathogenic phenuivirus infections focusing particularly on RVFV and SFTSV.

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Section: Gut Microbiota and Platelet In Phenuivirus Infectionmentioning

confidence: 99%

Current insights into human pathogenic phenuiviruses and the host immune system

Zhou,

Jiang,

Liu

et al. 2024

Virulence

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A symbiotic mosquito‐gut bacterium for flavivirus control

Wang,

Zhu,

Leng

et al. 2024

Clinical & Translational Med

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Dengue virus (DENV) and Zika virus (ZIKV) have emerged as major global public health challenges, causing numerous infections and fatalities each year. However, current measures, including vaccines and treatments, are often limited or ineffective. This highlights the urgent need for novel preventive strategies to control the spread of key mosquito‐borne viruses like DENV and ZIKV. In a recent study published in Science, Zhang et al. isolated a bacterium named Rosenbergiella_YN46 from the gut of field‐caught Aedes albopictus mosquitoes in Yunnan Province, China. This commentary reviews their findings, published on April 19, 2024, which describe the symbiotic bacterium Rosenbergiella_YN46 and its ability to block flavivirus transmission, including both DENV and ZIKV. The bacterium shows promising potential for future dengue fever prevention and provides valuable insights into a novel biological approach for controlling mosquito‐borne viral diseases.

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Role of Gut Microbiota in Dengue

Pedreañez,

Carrero,

Vargas

et al. 2024

Reviews in Medical Virology

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Dengue is a disease caused by a flavivirus (DENV) and transmitted by the bite of a mosquito, primarily the Aedes aegypti and Aedes albopictus species. Previous studies have demonstrated a relationship between the host gut microbiota and the evolution of dengue. It seems to be a bidirectional relationship, in which the DENV can affect the microbiota by inducing alterations related to intestinal permeability, leading to the release of molecules from microbiota dysbiosis that can influence the evolution of dengue. The role of angiotensin II (Ang II) in the microbiota/dengue relationship is not well understood, but it is known that the renin‐angiotensin system (RAS) is present in the intestinal tract and interacts with the gut microbiota. The possible effect of Ang II on the microbiota/Ang II/dengue relationship can be summarised as follows: the presence of Ang II induced hypertension, the increase in angiotensinogen, chymase, and microRNAs during the disease, the induction of vascular dysfunction, the production of trimethylamine N‐oxide and the brain/microbiota relationship, all of which are elements present in dengue that could be part of the microbiota/Ang II/dengue interactions. These findings suggest the potential use of Ang II synthesis blockers and the use of AT1 receptor antagonists as therapeutic drugs in dengue.

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A naturally isolated symbiotic bacterium suppresses flavivirus transmission byAedesmosquitoes

Cited by 13 publications

References 72 publications

Current insights into human pathogenic phenuiviruses and the host immune system

Current insights into human pathogenic phenuiviruses and the host immune system

A symbiotic mosquito‐gut bacterium for flavivirus control

Role of Gut Microbiota in Dengue

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