A negative component superimposed on event‐related potentials during light drowsiness

Sekine, Atsushi; Niiyama, Yoshitsugu; Kutsuzawa, Osamu; Shimizu, Tetsuo

doi:10.1046/j.1440-1819.2001.00892.x

Cited by 13 publications

(15 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently, Sekine et al . reported that P300 did not change in both amplitude and peak latency even when the awareness of subjects decreased from fully awake to light drowsiness 25 . Taking that result into consideration, we suggested that the changes of P300 during sleep deprivation are not due to drowsiness but due to cognitive decline.…”

Section: Discussionmentioning

confidence: 69%

Cognitive deterioration and changes of P300 during total sleep deprivation

Lee

Suh

2003

Psychiatry Clin Neurosci

View full text Add to dashboard Cite

The study was conducted to evaluate the cognitive deteriorations induced by sleep deprivation with the computerized neurocognitive tests and the P300 event-related potential. Thirty healthy college students (22 men, eight women) participated in the present study. Subjects remained awake for 38 h under continuous surveillance. In the morning and the evening of the two study days, the computerized neurocognitive tests and the P300 were performed. In vigilance test and reaction unit test, there were significant cognitive impairments during sleep deprivation. However, in the cognitrone test there was significant functional improvement, which might be due to the practice effect. The P300 latency was significantly prolonged and the amplitudes decreased during sleep deprivation. The cognitive impairment during 38 h of sleep deprivation was mainly in terms of vigilance and reaction time. In contrast, higher complex cognitive function such as fine perceptual analyses, visual discrimination and working memory might be not affected by 38 h of total sleep deprivation. The changes of P300 were significantly correlated with the results of vigilance and reaction unit tests but not with the cognitrone test. Taken together, these results suggest that the P300 changes that occur during sleep deprivation are a reflection of the decrement in vigilance, which prolongs reaction time.

show abstract

Section: Discussionmentioning

confidence: 69%

Cognitive deterioration and changes of P300 during total sleep deprivation

Lee

Suh

2003

Psychiatry Clin Neurosci

View full text Add to dashboard Cite

show abstract

“…A distracting task was also found to increase P3 latencies and decrease amplitude (Shucard et al 2004;Ramirez et al 2005). One study (Sekine et al 2001), however, reported no change in P300 latency and amplitude from fully-awake to light-drowsiness state.…”

Section: Discussionmentioning

confidence: 94%

Electrophysiological correlates of cognition improve with nap during sleep deprivation

et al. 2009

View full text Add to dashboard Cite

The efficacy of a 30-min nap as a countermeasure in the reduction of cognitive decline following 24 h of sleep deprivation (SD) on subjective sleepiness scales, event-related potential (ERP) P300, and contingent negative variation (CNV) was evaluated. The experiment was performed in three sessions on different days between 7 and 8 a.m. on nine normal, healthy males, of age 25-30 years: Session 1. Baseline recordings; Session 2, after one night's total sleep deprivation, and; Session 3, after 1 week of Session 1, following one night's sleep deprivation along with a 30-min nap opportunity between 1.00 and 3.00 a.m. Subjective sleepiness scores increased after SD as compared to baseline, but reduced significantly after nap (P < 0.05). There was an increase in P3 peak latency of ERP following SD (16%, P < 0.01), which was reduced with nap (10.7%, P < 0.05).There was an increase in CNV M1 peak latency after SD (18%) which decreased with the use of nap (12.5%) (P < 0.01). The CNV reaction time increased following SD (39.3%) and decreased with the use of nap (24%) (P < 0.01). No significant effects on ERP N1, P1, N2 latencies, P2 and P3 amplitudes and CNV N1, P3, M2 peak latencies and M1, and M2 amplitudes were observed. It was concluded that a 30-min nap, between 1.00 and 3.00 a.m. during night SD, reduces the cognitive decline following 24 h of SD in terms of its electro-physiological correlates. The study is of applied value in optimization of cognitive performance in professions demanding night work schedules.

show abstract

“…Subjective sleepiness and psychomotor performance were monitored every 20 min from 1000 to 1600 h. During the first 5 min of each 20 min epoch, the Visual Analog Scale (VAS) (Folstein and Luria, 1973), Stanford Sleepiness Scale (SSS) (Hoddes et al, 1973), and Choice Reaction Time (CRT) (Sekine et al, 2001) were applied consecutively.…”

Section: Methodsmentioning

confidence: 99%

“…CRT was used to assess objective psychomotor performance, as reported previously (Sekine et al, 2001). Two different brief tones (2000 and 1000 Hz), each with a duration of 100 ms, were generated by an automatic stimulator (Nihon Kohden SS-1449, Nihon Kohden, Tokyo, Japan) and presented at 60 dB (normal hearing level).…”

Section: Methodsmentioning

confidence: 99%

Heat Loss, Sleepiness, and Impaired Performance after Diazepam Administration in Humans

Echizenya

Mishima

Satoh

et al. 2003

Neuropsychopharmacol

Self Cite

View full text Add to dashboard Cite

In spite of the accumulation of knowledge regarding the neuropharmacological action of benzodiazepines (Bz), the physiological process by which their sedative/hypnotic effects are induced remains poorly understood. We conducted a single-blind, crossover trial to evaluate the role of the thermoregulatory process in sleepiness and impaired psychomotor performance induced by a standard Bz, diazepam (DZP). Each of the eight healthy young male volunteers (mean age, 19.75 years; range, 18-23 years) was given a single oral dose of either 5 or 10 mg of DZP or placebo 12 h after his average sleep onset time. Changes in plasma DZP concentration, proximal body temperature (p-BT), distal body temperature (d-BT), subjective sleepiness measured by the Visual Analog Scale and Stanford Sleepiness Scale, and psychomotor performance measured by Choice Reaction Time were monitored under a modified constant routine condition in which various factors affecting thermoregulation, alertness, and psychomotor performances were strictly controlled. Orally administered DZP induced a significant transient decrease in p-BT and psychomotor performance as well as an increase in d-BT and subjective sleepiness. DistalÀp-BT gradient (DPG; difference between d-BT and p-BT), which is an indicator of blood flow in distal skin regions, showed a strong positive correlation with the plasma DZP concentration, indicating that DZP in clinical doses promotes heat loss in a dose-dependent manner. The DPG also correlated positively with the magnitude of subjective sleepiness and impaired psychomotor performance. These findings indicate that the sedative/hypnotic effects of Bz could be due, at least in part, to changes in thermoregulation, especially in the process of heat loss, in humans.

show abstract

A negative component superimposed on event‐related potentials during light drowsiness

Cited by 13 publications

References 18 publications

Cognitive deterioration and changes of P300 during total sleep deprivation

Cognitive deterioration and changes of P300 during total sleep deprivation

Electrophysiological correlates of cognition improve with nap during sleep deprivation

Heat Loss, Sleepiness, and Impaired Performance after Diazepam Administration in Humans

Contact Info

Product

Resources

About