2005
DOI: 10.1111/j.1440-1681.2005.04214.x
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A Neglected ‘Accessory’ Vasomotor Pathway: Implications for Blood Pressure Control

Abstract: 1. Distinct from 'regular' sympathetic preganglionic neurons, there exists a population of 'accessory' preganglionic neurons. The latter are distinguishable by their unmyelinated axons and their different functional properties. They synapse on the same ganglion cells. 2. Ongoing sympathetic activity is driven by 'regular' preganglionic neurons. 3. 'Accessory' preganglionic neurons drive hexamethonium-resistant ganglionic transmission: part of this is muscarinic and part not (possibly peptidergic or nitrergic).… Show more

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Cited by 4 publications
(8 citation statements)
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“…It has been argued elsewhere, on the basis of physiological experiments, that two functional classes of SPN innervate vasomotor postganglionic neurons (Jänig et al, 1983; Jänig, 2005; McAllen et al, 2005): these have been termed ‘regular’ and ‘accessory’ (McAllen et al, 2005). The ‘regular’ pathway provides resting tone, is strongly activated by baroreceptor unloading and communicates with ganglion cells by conventional nicotinic transmission (Henderson and Ungar, 1978; Jänig, 1995).…”
Section: Discussionmentioning
confidence: 99%
“…It has been argued elsewhere, on the basis of physiological experiments, that two functional classes of SPN innervate vasomotor postganglionic neurons (Jänig et al, 1983; Jänig, 2005; McAllen et al, 2005): these have been termed ‘regular’ and ‘accessory’ (McAllen et al, 2005). The ‘regular’ pathway provides resting tone, is strongly activated by baroreceptor unloading and communicates with ganglion cells by conventional nicotinic transmission (Henderson and Ungar, 1978; Jänig, 1995).…”
Section: Discussionmentioning
confidence: 99%
“…Data from a range of experimental paradigms were presented at this conference that supported the notion that neural mechanisms contribute to long‐term blood pressure control and to the pathogenesis of hypertension in some clinical and experimental models 3,5–10 . There was considerable interest in the nature of the central and peripheral mechanisms involved 11–15 . There have also been recent advances in our understanding of the renal mechanisms that contribute to long‐term blood pressure control, dominated by extrinsic and intrinsic neurohumoral mechanisms and their interactions with the intrinsic pressure natriuresis mechanism 16–18 …”
Section: Recent Advances In Our Understanding Of Long‐term Blood Presmentioning
confidence: 83%
“…3,[5][6][7][8][9][10] There was considerable interest in the nature of the central and peripheral mechanisms involved. [11][12][13][14][15] There have also been recent advances in our understanding of the renal mechanisms that contribute to long-term blood pressure control, dominated by extrinsic and intrinsic neurohumoral mechanisms and their interactions with the intrinsic pressure natriuresis mechanism. [16][17][18]…”
Section: Recent Advances In Our Understanding Of Long-term Blood Presmentioning
confidence: 99%
“…Another possibility is that the presumed increase in GABAergic neurotransmission activates an "accessory" vasomotor pathway originating from the rostral VLM (McAllen et al, 2005). This pathway is thought to activate "accessory" sympathetic preganglionic neurons, which are characterized by their unmyelinated axons and which drive hexamethonium-resistant transmission in sympathetic ganglia (McAllen et al, 2005).…”
Section: Ventrolateral Medulla Vlmmentioning
confidence: 99%
“…This pathway is thought to activate "accessory" sympathetic preganglionic neurons, which are characterized by their unmyelinated axons and which drive hexamethonium-resistant transmission in sympathetic ganglia (McAllen et al, 2005). Unlike "regular" sympathetic preganglionic neurons, which are inhibited by administration of GABA in the rostral VLM, the "accessory" sympathetic preganglionic neurons are activated by this manipulation (McAllen et al, 2005). Thus, it may be that activation of this "accessory" pathway contributes to resting blood pressure differences between LCR and HCR rats.…”
Section: Ventrolateral Medulla Vlmmentioning
confidence: 99%