2018
DOI: 10.1155/2018/3951783
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A Network Pharmacology Analysis to Explore the Effect ofAstragali Radix-Radix Angelica Sinensison Traumatic Brain Injury

Abstract: Traumatic brain injury (TBI) is a critical public health and socioeconomic problem worldwide. The herb pair Astragali Radix (AR)-Radix Angelica Sinensis (RAS) is a common prescribed herbal formula or is added to other Chinese medicine prescriptions for traumatic brain injury (TBI) treatment. However, the underlying mechanisms are unclear. In this study, we aimed to explore the active ingredients and action targets of AR-RAS based on the combined methods of network pharmacology prediction and experimental verif… Show more

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Cited by 33 publications
(27 citation statements)
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“…Certain herbs used in traditional Chinese medicine have demonstrated neuroprotective effects and neurogenesis functions [50,51]. In animal studies of immature cortices, A. sinensis demonstrated neuroprotective effects following hypoxic brain damage [52]. Gastrodia elata can reduce brain edema and neuronal loss, and improve neural stem cell proliferation [53].…”
Section: Cerebral Infarction and Intracranial Hemorrhagementioning
confidence: 99%
“…Certain herbs used in traditional Chinese medicine have demonstrated neuroprotective effects and neurogenesis functions [50,51]. In animal studies of immature cortices, A. sinensis demonstrated neuroprotective effects following hypoxic brain damage [52]. Gastrodia elata can reduce brain edema and neuronal loss, and improve neural stem cell proliferation [53].…”
Section: Cerebral Infarction and Intracranial Hemorrhagementioning
confidence: 99%
“…Prediction of drug-likeness, oral bioavailability, and bloodbrain barrier Biological experiments require a considerable amount of time and human resources. Cognisant to this, ADME (absorption, distribution, metabolism, and excretion) studies are used to assess the drug transport process because it provides a convenient approach for research (Xie et al 2018). Herein, oral bioavailability (OB), blood-brain barrier (BBB), and drug-likeness (DL) were used to screen for the active components of the drug (Pang et al 2018;Xie et al 2018).…”
Section: Discussionmentioning
confidence: 99%
“…OB described the percentage of an oral dose capable of producing pharmacological activity. 26 DL was applied to determine the similarity of a compound to conventional drugs and its physicochemical properties. 27 Only compounds that had related targets and met the ADME criteria (ie, OB threshold≥30% and DL thresh-old≥0.18) were included in the study for subsequent research.…”
Section: Pharmacokinetic Adme Predictionmentioning
confidence: 99%