A Neural Basis for Developmental Topographic Disorientation

Kim, Jiye G.; Aminoff, Elissa; Kästner, Sabine; Behrmann, Marlene

doi:10.1523/jneurosci.0640-15.2015

Cited by 41 publications

(35 citation statements)

References 67 publications

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“…Specifically, the core network included regions like the PHG, RSC, and HIP, which are primarily responsible for three key components for successful navigation: visual scene processing (Epstein and Kanwisher 1998), spatial orientation (Marchette et al 2014;Kim et al 2015), cognitive map (O'Keefe and Dostrovsky 1971; Ekstrom et al 2003), respectively. Both neuroimaging and neuropsychological studies have suggested the critical behavioral importance of the core network.…”

Section: Discussionmentioning

confidence: 99%

“…In previous work, the RSC has been highlighted as an important area for navigation and route learning (Maguire et al 1998;Maguire 2001;Cain et al 2006;Cooper and Mizumori 2001;O'Craven and Kanwisher 2000). For instance, recent studies suggests that the RSC anchors our sense of direction to local environment (Marchette et al 2014), and that an alteration of the RSC's functional properties may serve as the neural basis for developmental topographic disorientation (DTD) (Kim et al 2015). Previous neuropsychological findings also showed that patients with damage in the RSC are unable to describe the relationship between locations and exhibited spatial navigation impairment (Takahashi et al 1997;Aguirre and D'Esposito 1999;Valenstein et al 1987;Vann et al 2009).…”

Section: Discussionmentioning

confidence: 99%

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Human navigation network: the intrinsic functional organization and behavioral relevance

Kong

Wang

et al. 2016

Brain Struct Funct

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Spatial navigation is a crucial ability for living. Previous work has revealed multiple distributed brain regions associated with human navigation. However, little is known about how these regions work together as a network (referred to as navigation network) to support flexible navigation. In a novel protocol, we combined neuroimaging meta-analysis, and functional connectivity and behavioral data from the same subjects. Briefly, we first constructed the navigation network for each participant, by combining a large-scale neuroimaging metaanalysis (with the Neurosynth) and resting-state functional magnetic resonance imaging. Then, we investigated multiple topological properties of the navigation networks, including small-worldness, modularity, and highly connected hubs. Finally, we explored the behavioral relevance of these intrinsic properties in a large sample of healthy young adults (N = 190). We found that navigation networks showed small-world and modular organization at global level. More importantly, we found that increased small-worldness and modularity of the navigation network were associated with better navigation ability. Finally, we found that the right retrosplenial complex (RSC) acted as one of the hubs in the navigation network, and that higher betweenness of this region correlated with better navigation ability, suggesting a critical role of the RSC in modulating the navigation network in human brain. Our study takes one of the first steps toward understanding the underlying organization of the navigation network. Moreover, these findings suggest the potential applications of the novel approach to investigating functionally meaningful networks in human brain and their relations to the behavioral impairments in the aging and psychiatric patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Human navigation network: the intrinsic functional organization and behavioral relevance

Kong

Wang

et al. 2016

Brain Struct Funct

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“…As control regions, retinotopic early visual areas (V1-V4) and the face-selective fusiform face area (FFA) were defined for each participant. Retinotopic areas were defined using a standard topographic mapping procedure from a separate scanning session (8,37), and FFA was defined based on the contrast faces vs. scenes. Figure 2 depicts the locations and BOLD time courses of LOC and PPA for LSJ and a representative control participant C1 for visualization purposes.…”

Section: Visual Selectivitymentioning

confidence: 99%

“…This adaptation phenomenon (also called repetition suppression or repetition attenuation) can be considered a form of rapid learning and a signature of perceptual memory for previously viewed stimuli. Adaptation has been observed in many visual regions including the lateral occipital cortex (LOC) for repeated presentations of objects (e.g., [1][2][3][4][5] and in the parahippocampal place area (PPA) for repeated presentations of scenes [6][7][8]. Adaptation occurs not only when a stimulus is repeated immediately (with no intervening stimuli), but also after a time lag of several minutes or longer during which intervening stimuli are presented (e.g., [9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Functions of ventral visual cortex after bilateral hippocampal loss

Kim

Gregory

Landau

et al. 2019

Preprint

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Repeated stimuli elicit attenuated responses in visual cortex relative to novel stimuli. This adaptation phenomenon can be considered a form of rapid learning and a signature of perceptual memory. Adaptation occurs not only when a stimulus is repeated immediately, but also when there is a lag in terms of time and other intervening stimuli before the repetition. But how does the visual system keep track of which stimuli are repeated, especially after long delays and many intervening stimuli? We hypothesized that the hippocampus supports long-lag adaptation, given that it learns from single experiences, maintains information over delays, and sends feedback to visual cortex. We tested this hypothesis with fMRI in an amnesic patient, LSJ, who has encephalitic damage to the medial temporal lobe resulting in complete bilateral hippocampal loss. We measured adaptation at varying time lags between repetitions in functionally localized visual areas that were intact in LSJ. We observed that these areas track information over a few minutes even when the hippocampus is unavailable. Indeed, LSJ and controls were identical when attention was directed away from the repeating stimuli: adaptation occurred for lags up to three minutes, but not six minutes. However, when attention was directed toward stimuli, controls now showed an adaptation effect at six minutes but LSJ did not. These findings suggest that visual cortex can support one-shot perceptual memories lasting for several minutes but that the hippocampus is necessary for adaptation in visual cortex after longer delays when stimuli are task-relevant.

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“…In more detail, lesions restricted to the hippocampus in humans result only in slight navigation impairments in familiar environments, but rather strongly impair learning or imagining new trajectories (Bohbot & Corkin, 2007;Clark & Maguire, 2016;Maguire, Intraub, & Mullally, 2016;Spiers & Maguire, 2006;Teng & Squire, 1999). In contrast, lesions in regions such as the parietal cortex or the retrosplenial cortex produce strong topographical disorientation in both familiar and new environments (Aguirre & D'Esposito, 1999;Habib & Sirigu, 1987;Kim, Aminoff, Kastner, & Behrmann, 2015;Maguire, 2001;Takahashi, Kawamura, Shiota, Kasahata, & Hirayama, 1997). This suggests that the core navigation processes (which may include transformations from allocentric representations to egocentric motor commands) is performed independently by neocortical (including parietal cortex) areas outside the hippocampus, which may utilize hippocampal information related to recent memories (Ekstrom, Arnold, & Iaria, 2014;Miller et al, 2013;Rolls & Wirth, 2018).…”

mentioning

confidence: 99%

Spatial coordinate transforms linking the allocentric hippocampal and egocentric parietal primate brain systems for memory, action in space, and navigation

Rolls

2019

Hippocampus

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A theory and model of spatial coordinate transforms in the dorsal visual system through the parietal cortex that enable an interface via posterior cingulate and related retrosplenial cortex to allocentric spatial representations in the primate hippocampus is described. First, a new approach to coordinate transform learning in the brain is proposed, in which the traditional gain modulation is complemented by temporal trace rule competitive network learning. It is shown in a computational model that the new approach works much more precisely than gain modulation alone, by enabling neurons to represent the different combinations of signal and gain modulator more accurately. This understanding may have application to many brain areas where coordinate transforms are learned. Second, a set of coordinate transforms is proposed for the dorsal visual system/parietal areas that enables a representation to be formed in allocentric spatial view coordinates. The input stimulus is merely a stimulus at a given position in retinal space, and the gain modulation signals needed are eye position, head direction, and place, all of which are present in the primate brain. Neurons that encode the bearing to a landmark are involved in the coordinate transforms. Part of the importance here is that the coordinates of the allocentric view produced in this model are the same as those of spatial view cells that respond to allocentric view recorded in the primate hippocampus and parahippocampal cortex. The result is that information from the dorsal visual system can be used to update the spatial input to the hippocampus in the appropriate allocentric coordinate frame, including providing for idiothetic update to allow for self‐motion. It is further shown how hippocampal spatial view cells could be useful for the transform from hippocampal allocentric coordinates to egocentric coordinates useful for actions in space and for navigation.

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A Neural Basis for Developmental Topographic Disorientation

Cited by 41 publications

References 67 publications

Human navigation network: the intrinsic functional organization and behavioral relevance

Human navigation network: the intrinsic functional organization and behavioral relevance

Functions of ventral visual cortex after bilateral hippocampal loss

Spatial coordinate transforms linking the allocentric hippocampal and egocentric parietal primate brain systems for memory, action in space, and navigation

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