Recently, deep learning has played an important role in the rise of artificial intelligence, and its accuracy has gained recognition in various research fields. Although engine phenomena are very complicated, they can be predicted with high accuracy using deep learning because they are based on the fundamentals of physics and chemistry. In this research, models were built with deep neural networks for gasoline engine prediction. The model consists of two sub-models. The first predicts the knock occurrence, and the second predicts performance, combustion, and emissions. This includes maximum cylinder pressure, crank angle at maximum cylinder pressure, maximum pressure rise rate, and brake mean effective pressure, brake-specific fuel consumption, brake-specific nitrogen oxides, and brake-specific carbon oxide, which are representative results of the engine (for normal combustion cases without knock). Model input parameters were selected considering engine operating conditions, and physically measurable sensor values. For test cases, the accuracy of the first model for knock classification is 99.0%, and the coefficient of determination (R2) values for the second model are all above 0.99. Test times of both models were approximately 2 ms. The robustness of all the models was verified using K-fold cross-validation. A sensitivity study of accuracy, according to the amount of training utilized, was also conducted to determine how many data points are required to effectively train the deep learning model. Accordingly, a deep learning approach was applied to predict the steady-state conditions of a gasoline engine. Achieved model accuracies and robustness proved deep learning to be an effective modeling approach, and test time was recognized to be able to apply for the real-time prediction. The sensitivity analysis can be applied for the preliminary study to define the number of experimental points for the deep learning model.