I. INTRODUCTIONBlood pressure (BP) is one of the four vital signs of human body besides heart rate, respiratory rate, and body temperature. Recently, the risk of having hypertension is extending from older to younger groups of the population. This trend making the number of people who need daily monitoring of BP is significantly increased. In addition, the demand for public resources in the hospital is becoming more and more serious and the type of healthcare is tending to individual-centered rather than hospital-centered. The need of self-monitoring BP devices dramatically increases in the recent decades. However, most of the commercial BP measuring devices require to inflate and deflate a cuff for determining the BP values. This measurement has a high demand for the medical practitioner"s operation skills.Self-monitoring BP devices using cuffless and noninvasive detective methods are very attractive for personal healthcare applications. It was reported that Manuscript received August 4, 2016; revised December 9, 2016 cuff-less, noninvasive, and continuous measurement of BP could be achieved by photoplethysmography (PPG) [1]- [7]. PPG [8] is a simple, portable and low-cost optical pulse that can be used to detect blood volume changes. The waveform of PPG is formed by heartbeat and affected by the condition of cardiovascular system [9]. When BP increases, the volumetric elasticity of blood vessel increases. This makes vessel wall stiff and the pulse wave propagation velocity is increased. The pulse wave propagation velocity (PWV) is represented as the pulse wave propagation distance divided by Pulse transit time (PTT). PTT is the time for the pulse wave to travel between two arterial sites, which is highly related with PWV. Normally, PTT is calculated from the time distance between R wave of ECG signal and following peak of fingertip PPG signal [10]. PTT based methods [5]-[7], [11]- [13] have been demonstrated to achieve relatively high accuracy on BP estimation, but two devices are required for the measurement. This is inconvenient and requires high operation skill in practical usage. Moreover, synchronization between two devices is also a big challenge of PTT approach. Therefore, PPG waveform analysis approach using a single PPG signal is very attractive for continuous and noninvasive BP measurement. However, several reported PPG waveform analysis based BP estimation methods [14], [15] From the recent studies [17], [18] of vascular aging through the second derivative of PPG (SDPPG), Pulse Wave Velocity (PWV) and SDPPG contain the information about aortic compliance and stiffness. These factors highly correlated with blood pressure. Basically, SDPPG is the acceleration of PPG and its waveform is in "W" shape with five sequential waves normally, as shown in the lower part of Fig. 1. These five waves are named as Initial Positive Wave (IPW), Early Negative Wave (ENW), Late Upsloping Wave (LUW), Late Downsloping Wave (LDW), and Diastolic Positive Wave (DPW). The positions of "a", "b", "c", "d", and "e" are peaks...