A Neural System that Represents the Association of Odors with Rewarded Outcomes and Promotes Behavioral Engagement

Gadziola, Marie A.; Stetzik, Lucas; Wright, Katherine N.; Milton, Adrianna J.; Arakawa, Keiko; Cortijo, María del Mar; Wesson, Daniel W.

doi:10.1016/j.celrep.2020.107919

Cited by 47 publications

(39 citation statements)

References 65 publications

(126 reference statements)

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“…Firing rate differences in a subset of cells emerged just before the odor port exit during which mice performed behavioral choices ( Figure 5 ). These features resembled the response pattern for learned odor-guided tasks observed in the piriform cortex ( Gadziola et al, 2020 ; Gire et al, 2013 ). However, many vTT cells increased their firing rate before the odor presentation ( Figures 1D , 2B and 4B ), and individual vTT cells exhibited a particular tuning pattern characterized by peak tuning and tuning duration.…”

Section: Discussionsupporting

confidence: 65%

Tuning of olfactory cortex ventral tenia tecta neurons to distinct task elements of goal-directed behavior

Shiotani

Tanisumi

Murata

et al. 2020

eLife

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The ventral tenia tecta (vTT) is a component of the olfactory cortex and receives both bottom-up odor signals and top-down signals. However, the roles of the vTT in odor-coding and integration of inputs are poorly understood. Here, we investigated the involvement of the vTT in these processes by recording the activity from individual vTT neurons during the performance of learned odor-guided reward-directed tasks in mice. We report that individual vTT cells are highly tuned to a specific behavioral epoch of learned tasks, whereby the duration of increased firing correlated with the temporal length of the behavioral epoch. The peak time for increased firing among recorded vTT cells encompassed almost the entire temporal window of the tasks. Collectively, our results indicate that vTT cells are selectively activated during a specific behavioral context and that the function of the vTT changes dynamically in a context-dependent manner during goal-directed behaviors.

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Section: Discussionsupporting

confidence: 65%

Tuning of olfactory cortex ventral tenia tecta neurons to distinct task elements of goal-directed behavior

Shiotani

Tanisumi

Murata

et al. 2020

eLife

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“…These findings suggest that the spatial pattern of neural activation in the OT encodes odor-induced attractive or aversive behaviors, in contrast to the odor map of the olfactory bulb. Consistent with this, electrophysiological recordings in behaving mice revealed that the firing activity of the OT flexibly encoded the valence of conditioned odors over odorant identity (Gadziola et al, 2015(Gadziola et al, , 2020. These studies suggest that OT neurons evaluate odorants in an experience-dependent manner and that spatially segregated domains and neuronal subtypes play distinct roles in inducing appropriate motivated behaviors.…”

Section: Functional Domains Of the Olfactory Tubercle And Odor-guidedsupporting

confidence: 57%

Hypothetical Roles of the Olfactory Tubercle in Odor-Guided Eating Behavior

Murata

2020

Front. Neural Circuits

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Olfaction plays an important role in the evaluation, motivation, and palatability of food. The chemical identity of odorants is coded by a spatial combination of activated glomeruli in the olfactory bulb, which is referred to as the odor map. However, the functional roles of the olfactory cortex, a collective region that receives axonal projections from the olfactory bulb, and higher olfactory centers in odor-guided eating behaviors are yet to be elucidated. The olfactory tubercle (OT) is a component of the ventral striatum and forms a node within the mesolimbic dopaminergic pathway. Recent studies have revealed the anatomical domain structures of the OT and their functions in distinct odor-guided motivated behaviors. Another component of the ventral striatum, the nucleus accumbens, is well known for its involvement in motivation and hedonic responses for foods, which raises the possibility of functional similarities between the OT and nucleus accumbens in eating. This review first summarizes recent findings on the domain- and neuronal subtype-specific roles of the OT in odor-guided motivated behaviors and then proposes a model for the regulation of eating behaviors by the OT.

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“…These connections provide ways which bring the olfactory input into close involvement with areas generating learning, emotion and olfactory-guided behavior. Of special interest is evidence showing direct connections of the tufted cells to the olfactory tubercle (Nagayama et al, 2010), and the role of the tubercle in olfactory-guided reward behavior (Gadziola et al, 2020). Given these multiple types of output, much of the olfactory cortex must reflect an organization of the olfactory input that can be sent to these distinct roles in these differing output systems.…”

Section: Output From the Posterior Olfactory Cortexmentioning

confidence: 99%

An Evolutionary Microcircuit Approach to the Neural Basis of High Dimensional Sensory Processing in Olfaction

Shepherd

Rowe

Greer

2021

Front. Cell. Neurosci.

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Odor stimuli consist of thousands of possible molecules, each molecule with many different properties, each property a dimension of the stimulus. Processing these high dimensional stimuli would appear to require many stages in the brain to reach odor perception, yet, in mammals, after the sensory receptors this is accomplished through only two regions, the olfactory bulb and olfactory cortex. We take a first step toward a fundamental understanding by identifying the sequence of local operations carried out by microcircuits in the pathway. Parallel research provided strong evidence that processed odor information is spatial representations of odor molecules that constitute odor images in the olfactory bulb and odor objects in olfactory cortex. Paleontology provides a unique advantage with evolutionary insights providing evidence that the basic architecture of the olfactory pathway almost from the start ∼330 million years ago (mya) has included an overwhelming input from olfactory sensory neurons combined with a large olfactory bulb and olfactory cortex to process that input, driven by olfactory receptor gene duplications. We identify a sequence of over 20 microcircuits that are involved, and expand on results of research on several microcircuits that give the best insights thus far into the nature of the high dimensional processing.

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A Neural System that Represents the Association of Odors with Rewarded Outcomes and Promotes Behavioral Engagement

Cited by 47 publications

References 65 publications

Tuning of olfactory cortex ventral tenia tecta neurons to distinct task elements of goal-directed behavior

Tuning of olfactory cortex ventral tenia tecta neurons to distinct task elements of goal-directed behavior

Hypothetical Roles of the Olfactory Tubercle in Odor-Guided Eating Behavior

An Evolutionary Microcircuit Approach to the Neural Basis of High Dimensional Sensory Processing in Olfaction

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