A neurokinin-1 receptor antagonist that reduces intra-abdominal adhesion formation decreases oxidative stress in the peritoneum

Reed, Karen L.; Heydrick, Stanley; Aarons, Cary B.; Prushik, Scott G.; Gower, Adam C.; Stucchi, Arthur F.; Becker, James M.

doi:10.1152/ajpgi.00226.2007

Cited by 44 publications

(31 citation statements)

References 50 publications

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“…47 Tissue injury results in bleeding and the resulting local hypoxia perpetuates endothelial permeability 48 with serosanguinous tissue exudation and leakage of lymphatic fluid, in addition to collection of blood, which occurs from transected vessels. Hypoxia resulting from injury acutely promotes O 2 À generation while the trauma itself disrupts stromal mast cells with release of vasoactive substances such as histamine and kinins, which enhance underlying fibroblasts migration and neutrophil recruitment to the wounded sites, 49 as well as decreased fibrinolytic activity. 50 The accumulation of red and white blood cells, macrophages, platelets, and tissue exudates forms a fibrinous mass, which, if persists, provides a fibrin matrix from which adhesion development occurs.…”

Section: Tissue Injury Hypoxia Oxidative Stress and Transcription mentioning

confidence: 99%

Advances in the Pathogenesis of Adhesion Development: The Role of Oxidative Stress

et al. 2014

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Over the past several years, there has been increasing recognition that pathogenesis of adhesion development includes significant contributions of hypoxia induced at the site of surgery, the resulting oxidative stress, and the subsequent free radical production. Mitochondrial dysfunction generated by surgically induced tissue hypoxia and inflammation can lead to the production of reactive oxygen and nitrogen species as well as antioxidant enzymes such as superoxide dismutase, catalase, and glutathione peroxidase which when optimal have the potential to abrogate mitochondrial dysfunction and oxidative stress, preventing the cascade of events leading to the development of adhesions in injured peritoneum. There is a significant cross talk between the several processes leading to whether or not adhesions would eventually develop. Several of these processes present avenues for the development of measures that can help in abrogating adhesion formation or reformation after intraabdominal surgery.

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Section: Tissue Injury Hypoxia Oxidative Stress and Transcription mentioning

confidence: 99%

Advances in the Pathogenesis of Adhesion Development: The Role of Oxidative Stress

et al. 2014

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“…ECP is a specific marker of eosinophils (Ursaciuc et al, 2010;Shah et al, 2012;Beigelman, 2014;Smith et al, 2015), which is mainly activated and released by eosinophils and causes neurotoxicity and cytotoxicity. In addition, ECP induces release of histamine by mast cells, causing airway hyperresponsiveness, resulting in bronchial asthma attack (Reed et al, 2007;Choi et al, 2010;Chua et al, 2010;Ursaciuc et al, 2010;Wei et al, 2010;Braga et al, 2011;Olive et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Eosinophil cationic protein mRNA expression in children with bronchial asthma

Yu¹,

Li²,

Zf³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Studies have shown that eosinophils are closely related to pathogenesis of bronchial asthma. Eosinophils release eosinophil cationic protein (ECP), which plays an important role in infection and allergic reactions. Serum ECP mRNA expression in children with bronchial asthma has not been adequately investigated. We analyzed serum ECP mRNA expression in 63 children with bronchial asthma and 21 healthy children by using reverse-transcriptase polymerase chain reaction to understand the role of ECP in children with bronchial asthma. The children with bronchial asthma were segregated into acutephase and stable-phase groups, based on the severity of the illness. Serum ECP mRNA expression in children with bronchial asthma (0.375 ± 0.04) was significantly higher than that in healthy controls (0.20 ± 0.02; P < 0.05). Additionally, children in the acute-phase group showed higher ECP mRNA expression level (0.44 ± 0.06) than those in the stablephase (0.31 ± 0.03) and healthy control groups (0.20 ± 0.02; P < 0.05), while the level in the stable-phase (0.31 ± 0.03) was markedly higher than that in the healthy control group (0.20 ± 0.02; P < 0.05). Detection of serum ECP mRNA expression level has possible applications in the diagnosis and treatment of children with bronchial asthma.

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“…In the same study, administration of neurokinin-1 receptor antagonist was reported to significantly increase the antioxidant capacity of the peritoneal fluid, which supports the suggestion that oxidative stress plays a role in adhesion formation. It was concluded in the study that reducing postoperative oxidative stress may result in decreased postoperative adhesions [30]. In the light of these data, drugs reducing oxidative stress were suggested to limit adhesion formation in animal models [8,31].…”

Section: Discussionmentioning

confidence: 99%

Honokiol Decreases Intra-Abdominal Adhesion Formation in a Rat Model

Ağaçayak

Tunç

İçen

et al. 2015

Gynecol Obstet Invest

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Aim: The purpose of this study was to investigate the effectiveness of honokiol, a natural molecule that was shown to have antioxidant effects, in prevention of intra-abdominal adhesion formation in a rat model. Material and Method: This study was conducted on a total of 40 non-pregnant Sprague-Dawley rats, which were divided into 4 groups as follows: sham, control, saline, and honokiol groups. Both uterine horns of the rats in control, saline, and honokiol groups were exposed and a 2-cm segment of the anti-mesenteric surface of both uterine horns was traumatized by a scalpel. The saline group was administered 2 ml of saline/day intraperitoneally for 5 days after the operation. The honokiol group, on the other hand, was administered honokiol intraperitoneally at a dose of 1 mg/kg/day for 5 days after the operation. On postoperative day 14, 3 ml of intracardiac blood sample was taken from the rats for biochemical analyses, and the rats were sacrificed this way. Results: Adhesion and inflammation scores were significantly lower in the honokiol group compared with the saline and control groups (p < 0.008). Similarly, fibrosis score was significantly lower in the honokiol group compared with the saline group (p < 0.008). Conclusion: Honokiol was found to be effective in prevention of intra-abdominal adhesion formation in a rat model. However, larger studies are needed to shed light on the exact role of honokiol in intra-abdominal adhesion formation and to determine the molecular aspects of the promising results found in this study.

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A neurokinin-1 receptor antagonist that reduces intra-abdominal adhesion formation decreases oxidative stress in the peritoneum

Cited by 44 publications

References 50 publications

Advances in the Pathogenesis of Adhesion Development: The Role of Oxidative Stress

Advances in the Pathogenesis of Adhesion Development: The Role of Oxidative Stress

Eosinophil cationic protein mRNA expression in children with bronchial asthma

Honokiol Decreases Intra-Abdominal Adhesion Formation in a Rat Model

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