Honokiol Decreases Intra-Abdominal Adhesion Formation in a Rat Model

Abstract

Aim: The purpose of this study was to investigate the effectiveness of honokiol, a natural molecule that was shown to have antioxidant effects, in prevention of intra-abdominal adhesion formation in a rat model. Material and Method: This study was conducted on a total of 40 non-pregnant Sprague-Dawley rats, which were divided into 4 groups as follows: sham, control, saline, and honokiol groups. Both uterine horns of the rats in control, saline, and honokiol groups were exposed and a 2-cm segment of the anti-mesenteric surface of both uterine horns was traumatized by a scalpel. The saline group was administered 2 ml of saline/day intraperitoneally for 5 days after the operation. The honokiol group, on the other hand, was administered honokiol intraperitoneally at a dose of 1 mg/kg/day for 5 days after the operation. On postoperative day 14, 3 ml of intracardiac blood sample was taken from the rats for biochemical analyses, and the rats were sacrificed this way. Results: Adhesion and inflammation scores were significantly lower in the honokiol group compared with the saline and control groups (p < 0.008). Similarly, fibrosis score was significantly lower in the honokiol group compared with the saline group (p < 0.008). Conclusion: Honokiol was found to be effective in prevention of intra-abdominal adhesion formation in a rat model. However, larger studies are needed to shed light on the exact role of honokiol in intra-abdominal adhesion formation and to determine the molecular aspects of the promising results found in this study.

Effect of Resveratrol on the Prevention of Intra-Abdominal Adhesion Formation in a Rat Model

“…In the rat intra-abdominal adhesion model generated by electrocautery to injure the peritoneum [25], Montalvo-Jave EE and colleagues used an anti-adherence compound consisting of a sodium hyaluronate and carboxymethylcellulose gel to reduce the degree of inflammatory infiltration and the number of adhesion lesions. Additionally, some natural compounds with anti-inflammatory and anti-oxidative actions, such as honokiol [26] and bromelain [27], also have effects on preventing the formation of intra-abdominal adhesions, to a certain extent. Our previous studies [16] also verified that adhesion formation in rat models can be prevented using anti-inflammatory drugs, such as selective COX-2 inhibitors.…”

Uterotonik Bir Ajandan Fazlası: Oksitosin Postoperatif Adezyonları Önlüyor

“…Reactive oxygen radicals (ROS) formed during hypoxia activate fibroblasts, causing the production of cytokines such as vascular endothelial growth factor (VEGF), tissue growth factor (TGF), and cyclooxygenase-2, which all increase adhesion formation [15,16] .…”

Application of Traditional Chinese Medicines in Postoperative Abdominal Adhesion

“…Honokiol, a biologically active substance derived from the bark of magnolia trees, has been shown to exert significant anti-inflammatory, antioxidative, antitumour and neuroprotective effects [31][32][33]. Agacayak et al [34] found that treatment with 1 mg/kg honokiol for 14 days was effective in prevention of PAA in a rat model. It may be related to its effects of anti-inflammatory and antifibrosis because the inflammation score and fibrosis score are significantly lower in the honokiol group compared with the saline group in the study.…”