A New Absorption Delaying Vehicle for Penicillin

Syphilis

“…Absorption-Delaying Vehicles : To the many absorption-delaying vehicles for penicillin now under investigation, Buckwalter and Dickison 176 propose peanut oil-aluminum stéarate gels as repository forms superior to peanut oil alone or peanut oil-beeswax combination. Ercoli and his co-workers,177 in studies made on dogs and on human subjects, found that epinephrine-oil preparations were effective in prolonging blood levels.…”

Treatment of Early Venereal Syphilis with Antibiotics

“…In Aqueous Suspension.-The discovery by Buckwalter and Dickison (1948) Although less easy to administer than procaine penicillin, this preparation has proved to be the natural successor to penicillin in oil-beeswax and is now the most widely used throughout the world, not only for venereal syphilis but also for endemic syphilis and the other treponematoses, yaws and pinta (see Langer and Kruger, 1952;Gay Prieto, Alvares Cascos, and Orusco, 1953;Vilanova and Alvarado, 1953;Cutler, Olansky, and Price, 1955, for venereal syphilis: Murray, Merriweather, and Freedman, 1956;Grin, 1956, for endemic syphilis: Hackett and Guthe, 1956;Samame, 1956;Zahra, 1956;Soetopo, Wasito, Soedarsono, and Tjokrodipo, 1956;Hume andFacio, 1956, for yaws: andRein, Kitchen, Marquez, andVarela, 1952, for pinta: see also Guthe and Willcox, 1954).…”

Treatment of Early Syphilis with Penicillin Alone

“…Sternberg and Leifer, 1947; and see Moore 1947). The difficulty created by the less successful results which were due to the varying amounts of the G fraction present in the earlier amorphous penicillins (U.S. Public Health Service, 1946) was successfully resolved by the isolation and production of crystalline (benzyl) penicillin G and by the introduction of repository preparations: penicillin in oil-beeswax (Romansky and Rittman, 1945), procaine penicillin (Buckwalter and Dickison, 1948), and procaine penicillin in oil with aluminium monostearate (PAM) and benzathine penicillin. The success of penicillin in the treatment of syphilis has since continued uninterrupted, and to-day there is no sign that T. pallidum is less sensitive to the antibiotic; allergic reactions, although occasionally troublesome in individual cases, offer no major obstacle to the routine treatment of the disease provided proper precautions are taken (W.H.O., 1960).…”