A new aminoglycoside antibiotic, substance AC4437.

Awata, Masashi; Muto, Naoki; Hayashi, Masahito; Yaginuma, Satoshi

doi:10.7164/antibiotics.39.724

Cited by 13 publications

(2 citation statements)

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“…Ring III (glucosamine) makes two direct contacts with 30S, neither of which are essential to activity [59,75]. Indeed, all of ring III can be dispensed with and cause only modest reductions in activity.…”

Section: Mechanism Of Actionmentioning

confidence: 99%

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Therapeutic Agents Acting on RNA Targets

Rife

2010

Burger's Medicinal Chemistry and Drug Discovery

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There are many therapeutics that target RNA, such as streptomycin, gentamicin, and tetracycline; some of them have been in existence for many years. All of them bind to ribosomal RNA and alter normal ribosome function. The modern strategies of drug discovery and design pertain nearly exclusively to protein targets. However, the field of drug discovery for RNA targets is maturing rapidly, largely due to the exciting ribosome/drug complexes that have recently been solved. Potential RNA drug targets abound for bacterial, viral, and cellular systems. Nevertheless, questions remain as to whether or not compounds can be found that simultaneously satisfy RNA binding and pharmacological properties, such as absorption and membrane permeation. The range of interactions observed, from Coulombic to hydrophobic, and the predicted “drug‐like” qualities of several ribosome binding antibiotics, suggest that the discovery of drugs that target RNA can be a general phenomenon.

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Section: Mechanism Of Actionmentioning

confidence: 99%

“…Several active natural streptomycin analogs, such as 5 0 -hydroxystreptomycin and AC4437, are hydroxylated at C5 0 [55,75]. Semisynthetic derivatives of this position are absent.…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Therapeutic Agents Acting on RNA Targets

Rife

2010

Burger's Medicinal Chemistry and Drug Discovery

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Therapeutic Agents Acting on RNA Targets

Rife¹

2003

Burger's Medicinal Chemistry and Drug Discovery

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There are many therapeutics that target RNA, such as streptomycin, gentamicin, tetracycline; some of them have been around for years. All of them bind to ribosomal RNA and alter normal ribosome function. The modern strategies of drug discovery and design pertain nearly exclusively to protein targets. However, the field of drug discovery for RNA targets is maturing rapidly, largely because of the exciting ribosome/drug complexes that have recently been solved. Potential RNA drug targets abound for bacteria, viral, and cellular systems. Nevertheless, questions remain as to whether or not compounds can be found that simultaneously satisfy RNA binding and pharmacological properties, such as absorption and membrane permeation. The range of interactions observed, from Coulombic to hydrophobic, and the predicted “drug‐like” qualities of several ribosome binding antibiotics suggest that the discovery of drugs that target RNA can be a general phenomenon.

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Aminoglycosides and Sugar Components in Other Secondary Metabolites

Piepersberg¹,

Distler²

1997

Biotechnology

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A new aminoglycoside antibiotic, substance AC4437.

Cited by 13 publications

References 0 publications

Therapeutic Agents Acting on RNA Targets

Therapeutic Agents Acting on RNA Targets

Therapeutic Agents Acting on RNA Targets

Aminoglycosides and Sugar Components in Other Secondary Metabolites

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