A New Anomaly of Eosinophilic Granulocytes

Ultrastructure of Human Eosinophils Genetically Lacking Peroxidase

“…The absence of peroxidase and phos pholipids in human eosinophils as a result of a genetic or hereditary defect has al ready been described by us in previous publications [9,12]. We found that the de fect was autosomal, recessive [11,12] and occasionally accompanied by hyperseg mentation of the nucleus and paucity of the specific granules [11].…”

Hereditary eosinophil peroxidase deficiency: immunochemical and spectroscopic studies and evidence for a compound heterozygosity of the defect.

“…It is a 70-kDa dimer composed of a 15-kDa light chain and a 55-kDa heavy chain held together by a disulfide bond (1). EPO deficiency was described for the first time by Presentey in 1968 (2) and about 100 subjects with the abnormality have been reported (3)(4)(5)(6). Cytochemical and biochemical family studies have suggested an autosomal recessive pattern of transmission ofthe defect in some subjects, while in others a definite pattern of transmission has not been established.…”

Eosinophil Peroxidase Deficiency in Humans and Mice.

“…Cytochemical and biochemical family studies suggested an autosomal recessive pattern of transmission of the defect in some subjects, while in others the patterns of transmission of the deficiency has not yet been established [21,23]. EPO deficiency does not manifest as any disease [20,21,23], though eosinophilia was masked in EPOdeficient subjects when they were examined using an automated cytochemistry based on the peroxidase technique (Technicon) [5].…”

“…The EPO deficiency in humans was characterized by cytochemical methods at the optical level [20,21]. Ultrastructural analysis of the EPO-deficient eosinophils of the families of two propositi revealed remarkable alterations in their specific granules in that the ratio between the core and matrix size appeared to be increased [22].…”