A new anti-inflammatory meroterpenoid from the fungus <i>Aspergillus terreus</i> H010

Zhao-ming, Liu; Liu, Hongju; Chen, Yan; She, Zhigang

doi:10.1080/14786419.2017.1375924

Cited by 33 publications

(20 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a similar research, Chen et al ( 2017 ) reported that culture extracts of the endophytic fungus Lasiodiplodia theobromae isolated from A. ilicifoliu s showed anti-inflammatory activities and they isolated some active components from the extracts including Lasiodiplactone A, an unprecedented lactone that possesses a unique tetracyclic system. Compounds such as meroterpenoid identified from Aspergillus terreus H010, an endophytic fungus from Kandelia obovata , also exhibited anti-inflammatory activities (Liu et al 2017 ). Results from these reports and those from our study strongly support the view that endophytic fungi of mangrove plants are promising sources of natural bioactive compounds (Stierle et al 1993 ; Strobel et al 1997 ; Strobel and Daisy 2003 ; Chen et al 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial and iNOS inhibitory activities of the endophytic fungi isolated from the mangrove plant Acanthus ilicifolius var. xiamenensis

et al. 2019

View full text Add to dashboard Cite

BackgroundAcanthus ilicifolius var. xiamenensis (Acanthaceae) is an old world mangrove species and has long been used as a folk remedy for treating various ailments in traditional medicine. The nature source of A. ilicifolius var. xiamenensis is now in short supply because of the urban development and habitat destruction. To better utilize this resource, biodiversity and bioactivity of endophytic fungi isolated from A. ilicifolius var. xiamenensis were investigated.ResultsA total of 168 fungal isolates were cultured from leaves and stems of the mangrove plant collected in January (winter) and July (summer) 2014 at Kinmen County, Taiwan. Spent culture extract of 28 isolates were found to have bioactivities against one of the following pathogenic microorganisms: the bacteria Bacillus subtilis, Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative) and the fungi Candida albicans and Cryptococcus neoformans. These positive extracts were mostly active against the Gram-positive bacteria and C. albicans. Corynespora cassiicola NTOU4889 and Xylaria sp. NTOU4900 inhibited growth of all 3 test bacteria whereas Phellinus noxius NTOU4917 inhibited both test fungi. A further anti-inflammatory study of culture extracts of these 28 isolates revealed that extracts with a high iNOS inhibition caused a low viability of cells, and those with a low iNOS inhibition had a high cell viability. Three extracts showed low cytotoxicity (i.e. > 100% cell viability) and high iNOS inhibition (< 15% of NO production) of cells and they were Phoma sp. 2 NTOU4338, Nodulisporium sp. NTOU4868 and Guignardia sp. NTOU4871.ConclusionThese results indicate that the endophytic fungi associated with A. ilicifolius var. xiamenensis can be a potential source of novel natural active substance.

show abstract

Section: Discussionmentioning

confidence: 99%

Antimicrobial and iNOS inhibitory activities of the endophytic fungi isolated from the mangrove plant Acanthus ilicifolius var. xiamenensis

et al. 2019

View full text Add to dashboard Cite

show abstract

“…In addition, the fermentation supernatant and mycelia of these fungi presented antibacterial activities [ 17 ]. Previous studies discovered and tested the anti-inflammatory effects of A. terreus derived compounds, such as butenolide derivatives [ 18 , 19 ] and meroterpenoids [ 20 ]. A butyrolactone I analogue, asperteretal A, significantly decreased the NO production in RAW264.7 cells [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Butyrolactone-I from Coral-Derived Fungus Aspergillus terreus Attenuates Neuro-Inflammatory Response via Suppression of NF-κB Pathway in BV-2 Cells

Zhang

Yao

et al. 2018

Marine Drugs

View full text Add to dashboard Cite

Butyrolactone-I (ZB5-1) from the coral-derived fungus Aspergillus terreus was investigated in this study to estimate its anti-neuroinflammatory effects on lipopolysaccharide (LPS)-induced BV-2 microglia cells. MTT assay indicated that ZB5-1 in tested concentrations had no cytotoxicity on BV-2 cells, and significantly reduced the production of nitric oxide (NO), measured using Griess reagent, and interleukin-1 beta (IL-1β), detected by enzyme-linked immunosorbent assay (ELISA). ZB5-1 also down-regulated the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in a dose-dependent manner by Western blot analysis. Moreover, the effect of ZB5-1 on the nuclear factor-κB (NF-κB) signaling pathway was studied via the expression of phosphorylation of NF-κB p65 and inhibitor of NF-κB (IκB), and the nuclear translocation of NF-κB p65 respectively. The results showed that ZB5-1 could inhibit the phosphorylation of p65 and IκB. Furthermore, molecular docking study suggested that ZB5-1 bound at the active sites of NF-κB to prevent its translocation to the nucleus. Therefore, we suggest ZB5-1 has a potential to reduce the anti-inflammatory response in LPS-induced BV-2 cells.

show abstract

“…The stereochemistry configurations of known compounds, preaustinoid A2, isoaustinol, dehydroaustin, and dehydroaustinol, were first determined by XRD, and the latter three molecules displayed anti-acetylcholinesterase (anti-AchE) activity (IC 50 = 0.4~3 µM) [101]. An unusual austinoid, 1,2-dehydro-terredehydroaustin (327), from the mangrove-derived fungus Aspergillus terreus H010, showed weak anti-inflammatory (NO) effects in RAW 246.7 cells (IC 50 42.3 µM vs. 30.7 µM for indomethacin) [102]. The marine endophytic fungus of the brown alga, Aspergillus sp.…”

Section: Aspergillus Spmentioning

confidence: 99%

A Review of Terpenes from Marine-Derived Fungi: 2015–2019

Jiang

Guo

et al. 2020

Marine Drugs

View full text Add to dashboard Cite

Marine-derived fungi are a significant source of pharmacologically active metabolites with interesting structural properties, especially terpenoids with biological and chemical diversity. In the past five years, there has been a tremendous increase in the rate of new terpenoids from marine-derived fungi being discovered. In this updated review, we examine the chemical structures and bioactive properties of new terpenes from marine-derived fungi, and the biodiversity of these fungi from 2015 to 2019. A total of 140 research papers describing 471 new terpenoids of six groups (monoterpenes, sesquiterpenes, diterpenes, sesterterpenes, triterpenes, and meroterpenes) from 133 marine fungal strains belonging to 34 genera were included. Among them, sesquiterpenes, meroterpenes, and diterpenes comprise the largest proportions of terpenes, and the fungi genera of Penicillium, Aspergillus, and Trichoderma are the dominant producers of terpenoids. The majority of the marine-derived fungi are isolated from live marine matter: marine animals and aquatic plants (including mangrove plants and algae). Moreover, many terpenoids display various bioactivities, including cytotoxicity, antibacterial activity, lethal toxicity, anti-inflammatory activity, enzyme inhibitor activity, etc. In our opinion, the chemical diversity and biological activities of these novel terpenoids will provide medical and chemical researchers with a plenty variety of promising lead compounds for the development of marine drugs.

show abstract

A new anti-inflammatory meroterpenoid from the fungus Aspergillus terreus H010

Cited by 33 publications

References 32 publications

Antimicrobial and iNOS inhibitory activities of the endophytic fungi isolated from the mangrove plant Acanthus ilicifolius var. xiamenensis

Antimicrobial and iNOS inhibitory activities of the endophytic fungi isolated from the mangrove plant Acanthus ilicifolius var. xiamenensis

Butyrolactone-I from Coral-Derived Fungus Aspergillus terreus Attenuates Neuro-Inflammatory Response via Suppression of NF-κB Pathway in BV-2 Cells

A Review of Terpenes from Marine-Derived Fungi: 2015–2019

Contact Info

Product

Resources

About