Spam messages are an increasing threat to mobile communication. Several mitigation techniques have been proposed, including white and black listing, challenge-response and content-based filtering. However, none are perfect and it makes sense to use a combination rather than just one. We propose an anti-spam framework based on the hybrid of content-based filtering and challenge-response. There is the trade-offs between accuracy of anti-spam classifiers and the communication overhead. Experimental results show how, depending on the proportion of spam messages, different filtering parameters should be set.