A technique for design optimization of a combustor is presented. This technique entails the use of computational fluid dynamics (CFD) and mathematical optimization to minimize the combustor exit temperature profile. The empirical and semi-empirical correlations commonly used for optimizing combustor exit temperature profile do not guarantee optimum. As an experimental approach is time consuming and costly, use is made of numerical techniques. However, using CFD without mathematical optimization on a trial and error basis does not guarantee optimal solutions. A better approach, which is often viewed as too expensive, is a combination of the two approaches, thus incorporating the influence of the variables automatically. In this study the combustor exit temperature profile is optimized. The optimum (uniform) combustor exit temperature profile mainly depends on the geometric parameters. Combustor parameters have been used as optimization variables. The combustor investigated is an experimental liquid-fuelled atmospheric combustor with a turbulent diffusion flame. The CFD simulations use the Fluent code with a standard k-ε model. The optimization is carried out using the Dynamic-Q algorithm, which is specifically designed to handle constrained problems where the objective and constraint functions are expensive to evaluate. The optimization leads to a more uniform combustor exit temperature profile compared with the original.