Big data is one of the promising technologies which helps the healthcare sector improve patient experience, reduce the cost of treatment, predict epidemics, and provide competitive healthcare services. This research aims to study and analyse big data architecture for a public hospital in Thailand.Study design/methodology/approach: This research employs a qualitative approach. For data collection and analysis, document analysis is applied as a qualitative method to obtain empirical data. In addition, in-depth interviews of the IT manager, doctor, and staff are conducted to confirm the big data architecture and examine issues in a case study public hospital.Findings: According to the study, big data architecture for the public hospital comprises data acquisition, data integration, data analytics, data visualisation, a health data centre on a cloud, and data governance.Originality/value: The architecture components and analysis can be applied as a guideline for big data processing and analytics to create a solution for implementing big data in healthcare effectively.