A new biflavonoid from<i>Ochna Beddomei</i>

Jayakrishna, Galla; Reddy, M. Kesava; Jayaprakasam, B.; Gunasekar, Duvvuru; Blond, A.; Bodo, Bernard

doi:10.1080/1028602021000034100

Cited by 12 publications

(9 citation statements)

References 6 publications

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“…Ochna obtusata DC (Rao et al, 1997), the stem bark of Ochna beddomei Gamble (Jayakrishna et al, 2003;Rao et al, 1997) and Ochna lanceolata Spreng, and the aerial parts of Selaginella labordei Hieron.…”

Section: Natural Resources and Derivativesmentioning

confidence: 99%

Advances in resources, biosynthesis pathway, bioavailability, bioactivity, and pharmacology of ochnaflavone

Lin,

Ganesan,

Vargas‐De‐La‐Cruz

et al. 2024

Future Postharvest and Food

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Ochnaflavone is a naturally occurring biflavonoid mainly isolated from Ochna integerrima, manifests health benefits encompassing antidiabetic, anticancer, anti‐cardiovascular, and anti‐inflammatory activities. However, most bioactivity research has focused on in vitro experiments, rather than in vivo disease models, toxicological assessments, and human clinical trials. Moreover, a comprehensive review of the pharmacological aspects of ochnaflavone is conspicuously lacking. Thus, this review provides a concise and comprehensive summary of existing knowledge on the chemical structure, plant origin, physical properties, biotransformations, and multifaceted biological activities of ochnaflavone along with an in‐depth exploration of the complex molecular mechanisms behind these activities, including signaling pathways and gene expression regulation, with the aim of promoting future theoretical needs for ochnaflavone in clinical trials and providing comprehensive insights into the research and application of this valuable natural compound.

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Section: Natural Resources and Derivativesmentioning

confidence: 99%

Advances in resources, biosynthesis pathway, bioavailability, bioactivity, and pharmacology of ochnaflavone

Lin,

Ganesan,

Vargas‐De‐La‐Cruz

et al. 2024

Future Postharvest and Food

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“…Ochna beddomei Gamble. (Leaves and stem bark) [23], Ochna integerrima (Louri) Merr. (leaves) [24], Ochna lanceolata Spreng.…”

Section: Natural Sourcesmentioning

confidence: 99%

“…[26], the stem bark of Ochna beddomei Gamble. [23,26] and Ochna lanceolata Spreng. [25], and the aerial parts of Selaginella labordei Hieron.…”

Section: Natural Sourcesmentioning

confidence: 99%

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Ochnaflavone, a Naturally Occuring Biflavonoid: Pharmacology and Prospects for Future Research

Ndoile¹

2018

ACRI

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Aims: To profile and address matters surrounding ochnaflavone (1), derivatives and analogues. Methodology: Papers concerning ochnaflavone, derivatives and analogues were accessed from search engines such as google scholar and pubmed. Results: Ochnaflavone and derivatives are compounds bearing ether linkage between the two Brings of the two flavonoid moieties. These compounds are known to possess potent biological activities such as anti-inflammatory, anticancer, anti HIV and antimicrobial. Conclusion:In this paper, an overview summary of ochnaflavone, derivatives and analogues from past to present is presented. Thus, the paper provides a sense of focus to researchers; seal breaks the unattended matters, and therefore, spearheads new research areas concerning these compounds.

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“…1). This biflavonoid is mainly isolated from Lonicera japonica (a family of Caprifoliaceae) in East Asia and Ochna species, for example, Ochna beddomi and O. integerrima (a family of Ochnaceae) that are mostly distributed in South Asia and Africa (Jayaprakasam et al, 2000;Jayakrishna et al, 2003;Reutrakaul et al, 2007). Regarding antiinflammation, Och was shown to have inhibitory effects on the iNOS expression Suh et al, 2006) and COX-2 and 5-LOX functions as well .…”

Section: Introductionmentioning

confidence: 97%

Involvement of T-cell immunoregulation by ochnaflavone in therapeutic effect on fungal arthritis due to Candida albicans

Lee

2011

Arch. Pharm. Res.

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Arthritis due to pathogenic fungi is a serious disease causing rapid destruction of the joint. In the pathogenesis of arthritis, T lymphocytes are considered to be one of the major immune cells. In present study, we examined the T cell immunoregulatory effect by ochnaflavone (Och), a biflavonoid, on arthritis caused by Candida albicans that is the most commonly associated with fungal arthritis. To examine the effects of ochnaflavonon Candida albicans-caused septic arthritis, an emulsified mixture of C. albicans cell wall and complete Freund's adjuvant (CACW/CFA) was injected into BALB/c mice via hind footpad route on days -3, -2, and -1. On Day 0, Och at 1 or 2 mg/dose/time was intratraperitoneally given to mice with the swollen footpad every other day for 3 times. The footpad-edema was measured for 20 days. Results revealed that Och reduced the edema at all dose levels and furthermore, there was app. 45% reduction of the edema in animals given 2 mg-dose at the peak of septic arthritis (p < 0.05). This anti-arthritic effect was accompanied by the diminishing of the DTH (delayed type hypersensitivity) activity against the CACW and by the provoking of the dominant T helper 2 (Th2) type cytokines production (IL-4 and Il-10), which appeared to result in a suppression of T helper 1 cytokines (IFN-γ and IL-2). Besides the T cell immunoregulatory activity, Och inhibited T cells activation as evidenced by the IL-2 reduction from PMA/ionomycin-stimulated Jurkat cell line and in addition, the compound killed macrophages in a dose-dependent manner (p < 0.05). However, Och caused no hemolysis (p < 0.05). These data implicate that Och, which has anti-arthritic activity based on the Th2 dominance as well as macrophage removal, can be safely administered into the blood circulation for treatment of the arthritis caused by C. albicans. Thus, it can be concluded that Och would be an ideal immunologically evaluated agent for treating of Candida arthritis.

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A new biflavonoid fromOchna Beddomei

Cited by 12 publications

References 6 publications

Advances in resources, biosynthesis pathway, bioavailability, bioactivity, and pharmacology of ochnaflavone

Advances in resources, biosynthesis pathway, bioavailability, bioactivity, and pharmacology of ochnaflavone

Ochnaflavone, a Naturally Occuring Biflavonoid: Pharmacology and Prospects for Future Research

Involvement of T-cell immunoregulation by ochnaflavone in therapeutic effect on fungal arthritis due to Candida albicans

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