A new C₂₀-diterpenoid alkaloid from Aconitum soongaricum var. pubescens

Abstract

A new denudatine-type C-diterpenoid alkaloid, pubesine (1), along with seven known diterpenoid alkaloids, altaconitine (2), 14-benzoylaconine (3), spicatine A (4), 14-benzoylaconine-8-palmitate (5), 14-O-acetylsenbusine A (6), senbusine A (7) and 14-acetylneoline (8) were isolated from the whole plant of Aconitum soongaricum var. pubescens. Their structures were elucidated by means of extensive spectroscopic analyses (NMR and HR-ESI-MS) and comparison with data reported in the literature. All compounds were evaluated for their cytotoxicity against H460, MCF-7 and Hep G2 human cancer cell lines.

Classification, Toxicity and Bioactivity of Natural Diterpenoid Alkaloids

“…A hydroxyl group and an oxygenated group are respectively on C16 and C17 in DAs 117–120 . Finally, an epoxy group between C16 and C17 is visible in DAs 123–125 [ 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 ].…”

“…These two compounds show a 7,20-aza- ent -kaurane skeleton instead of a 19,20. Moreover, the DA- 157 exhibit a lactone between C11 and C16 [ 74 , 88 , 109 , 110 ].…”

Two New C19‐Diterpenoid Alkaloids from Delphinium shawurense

“…[8] In our previous phytochemical research on this plant, 17 diterpenoid alkaloids were obtained. [9 -11] Further investigation on this plant for additional biologically active substances with novel structures led to the isolation of two new C 19 -diterpenoid alkaloids, shawurenine C (1a) and D (1b), along with five known diterpenoid alkaloids, N-deethylmethyllycaconitine (2), 14-deacetylnudicauline (3), delbrunine (4), delectinine (5), and delsoline (6). Their structures (Figure 1), elucidated by spectroscopic analyses and compared with reported data, are found in the literature.…”

Diterpenoid alkaloids from Aconitum brevicalcaratum as autophagy inducers

“…In previous reports, eight diterpene alkaloids from this plant have been isolated and identified (Li & Chen 1994a, 1994b. The diterpenoid alkaloids are the characteric ingredients displaying various bioactivities (Yin et al 2014;Shyaula et al 2015;Chen et al 2016;Liang et al 2017). However, the bioactivities have not been studied yet, which prompted us to undertake a systematic study of this plant.…”