A new chiral electrochemical sensor for the enantioselective recognition of penicillamine enantiomers

Abstract

A new chiral electrochemical sensor has been successfully prepared through chemical linking L-methotrexate (L-Mtx) onto the gold electrode surface. Cyclic voltammetry and electrochemical impedance spectroscopy were used to investigate the enantioselective interaction between L-Mtx and Pen enantiomers. The results showed that the L-Mtx-modified gold electrode can selectively recognize penicillamine (Pen) enantiomers using Zn(II) as central ion, and larger response signal was observed from D-Pen owing to the selective formation of Zn complexes. The interaction time between the modified electrode and Pen enantiomers containing Zn(II) was considered. And the electrochemical response of the modified electrode to a series of different concentration of Pen in the presence of Zn(II) was also monitored. In addition, the enantiomeric composition of D-and L-Pen enantiomer mixtures was monitored by measuring the current responses of the sample.

Enantioseparation/Recognition based on nano techniques/materials

“…Furthermore, the binding dynamics and kinetics of complex molecules on complex surfaces are difficult to quantify in terms of interactions, adsorption sites, electron charge transfer, and so on; consequently, chiral sensing is a tough endeavor that is still in its early stages [259,260]. To date, numerous approaches for fast and accurate enantiomer discrimination have been developed, including electrochemical sensors [261][262][263][264][265][266][267][268][269][270], gravimetric-mass sensors-resonators [271][272][273][274], electrical sensors [275][276][277][278], and chiroptical/spectroscopic sensors [102,[279][280][281][282][283][284][285]. There are also examples where NPs have been used for chiral sensing [286].…”

A Voltammetric Sensory System for Recognition of Propranolol Enantiomers Based on Glassy Carbon Electrodes Modified by Polyarylenephthalide Composites of Melamine and Cyanuric Acid

“…Among EES, voltammetric enantioselective sensors are of particular interest , as they are more sensitive and universally applicable in comparison with potentiometric sensors. However, they are characterised by relatively low selectivity because the oxidation/reduction peaks on the voltammograms and the analytical signals of many enantiomers have slight differences.…”

A new chiral electrochemical sensor for the enantioselective recognition of naproxen enantiomers using l-cysteine self-assembled over gold nanoparticles on a gold electrode

“…26 Chen et al reported a gold electrode modified by Cu(II) and l-cysteine for chiral recognition of tryptophan enantiomers. 30 Zhang et al constructed a chiral electrochemical sensor by means of adsorbing human serum albumin onto a methylene blue-multi-wall carbon nanotubes nanohybrid modified glassy carbon electrode for the discrimination of tryptophan enantiomers . 28 Guo et al designed chiral sensor for enantioselective recognition of Nap enantiomers using BSA biofunctionalized reduced grapheme oxide nanosheets.…”

“…29 Chen et al fabricated a chiral electrochemical sensor through chemically linking L-methotrexate onto a gold electrode surface for the enantioselective recognition of penicillamine enantiomers. 30 Zhang et al constructed a chiral electrochemical sensor by adsorbing human serum albumin onto a methylene blue-multi-wall carbon nanotube nanohybrid modied glassy carbon electrode for the discrimination of tryptophan enantiomers. 31 The present sensors with high sensitivity, simplicity, low cost, low-power requirements, and high compatibility have been a preferable approach for the chiral recognition of Nap enantiomers.…”