A new class of half-sandwich ruthenium complexes containing Biginelli hybrids: anticancer and anti-SARS-CoV-2 activities

Janković, Nenad; Milović, Emilija; Jovanović, Jelena Đorović; Marković, Zoran; Stanojković, Tatjana; Matić, Ivana Z.; Crnogorac, Marija Đorđić; Klisurić, Olivera R.; Cvetinov, Miroslav; Bukhari, Syed Nasir Abbas

doi:10.1016/j.cbi.2022.110025

Cited by 16 publications

(12 citation statements)

References 53 publications

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“…A series of Biginelli hybrids were synthesized and liganded to Ru(II) [ 61 ]. The antiproliferative activity (MTT, 48 h exposure) against a panel of cancer cell lines of the series of ligands was moderate.…”

Section: Novel Metal Complexes In Cancer Therapymentioning

confidence: 99%

Recent Trends in the Development of Novel Metal-Based Antineoplastic Drugs

Todorov

Kostova

2023

Molecules

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Since the accidental discovery of the anticancer properties of cisplatin more than half a century ago, significant efforts by the broad scientific community have been and are currently being invested into the search for metal complexes with antitumor activity. Coordination compounds of transition metals such as platinum (Pt), ruthenium (Ru) and gold (Au) have proven their effectiveness as diagnostic and/or antiproliferative agents. In recent years, experimental work on the potential applications of elements including lanthanum (La) and the post-transition metal gallium (Ga) in the field of oncology has been gaining traction. The authors of the present review article aim to help the reader “catch up” with some of the latest developments in the vast subject of coordination compounds in oncology. Herewith is offered a review of the published scientific literature on anticancer coordination compounds of Pt, Ru, Au, Ga and La that has been released over the past three years with the hope readers find the following article informative and helpful.

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Section: Novel Metal Complexes In Cancer Therapymentioning

confidence: 99%

Recent Trends in the Development of Novel Metal-Based Antineoplastic Drugs

Todorov

Kostova

2023

Molecules

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“…3,4‐DHPMs and their derivatives are considered as “privileged structures” of immense biological potential. DHPMs exhibit wide range of biological properties like anti‐inflammatory, [ 54 ] anti‐HIV, [ 55 ] antifungal, [ 56 ] antioxidant, [ 57 ] anticancer, [ 58 ] antibacterial, [ 59 ] antihypertensive, [ 60 ] analgesic, [ 61 ] anticonvulsant, [ 62 ] antisevere acute respiratory syndrome, [ 63 ] and antifilarial activity. [ 64–69 ] Therefore, there is a need of the development of new synthetic protocols to access these existing and novel structural motifs.…”

Section: Curcuminoids In Mcrsmentioning

confidence: 99%

Curcumin‐based bioactive heterocycles derived via multicomponent reactions

Nagargoje

Shaikh

Shingate

2023

Archiv der Pharmazie

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Curcumin is an important phytochemical, found in the Asian countries, especially in the Indian subcontinent. The use of this "privileged natural product" in the diversityoriented synthesis of curcumin-based heterocycles via multicomponent reactions (MCRs) is the subject of interest for many medicinal chemists across the globe. This review particularly focuses on the reactions involving curcuminoids as one of the reactants in the MCRs of curcuminoid to synthesize curcumin-based heterocycles.Also, the various pharmacological activities of curcumin-based heterocycles generated via the MCR approach are discussed. The research work published in the last 10 years is in the focus of this review article.

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“…In the thurst of a new Metallo-antiviral discovery, the half sandwich compounds of ruthenium ( Ru-1 to Ru-5 , Fig. 5 ) were prepared using dichloro( p -cymene)ruthenium(II) precursor, and five different Biginelli hybrids [ 67 ]. These compounds were further investigated against SARS-CoV-2 main protease for their antiviral functionality using molecular docking simulations.…”

Section: Metal-based Antiviral Perspective and The Discovery Approachmentioning

confidence: 99%