A New Class of Phantom Materials for Poroelastography Imaging Techniques

Non-invasive imaging of interstitial fluid transport parameters in solid tumors in vivo

“…Polyacrylamide phantoms can be used as good tissue mimic phantoms 54 and were used to validate the proposed theories. Three non-uniform (with inclusion) phantoms were created using a combination of tofu and polyacrylamide gel following the protocol reported in 54 .…”

“…Polyacrylamide phantoms can be used as good tissue mimic phantoms 54 and were used to validate the proposed theories. Three non-uniform (with inclusion) phantoms were created using a combination of tofu and polyacrylamide gel following the protocol reported in 54 . In the non-uniform tissue mimicking phantoms, the background was made of tofu (Morinaga Nutritional Foods, Inc., Torrance, CA USA) while the inclusion (simulating the poroelastic tumor) was made of polyacrylamide gel.…”

Investigation of PolyVinyl Chloride Plastisol Tissue-Mimicking Phantoms for MR- and Ultrasound-Elastography

“…Ideally, elastography-dedicated TMP are expected to offer the following features: 1) Their mechanical properties (such as elasticity, viscosity, anisotropy, porosity or hyperelasticity) must be well controlled and must lie within typical values of soft tissues they are supposed to mimic; 2) They should offer particular ease of use in terms of storage conditions and durability; 3) They must be compatible with the medical imaging modality for which they have been developed. Several studies have proposed elastography TMP that display particular mechanical properties beyond linear elasticity, such as viscosity [43,65,74], poroelasticity [5], anisotropy [6][7][8][9][10], hyperelasticity [11][12][13], heterogeneity [14][15][16][17][18][19] and TMP including dynamic flow pulsations [20]. Inclusion of anisotropy [9] or porosity could be obtained through the addition of fibrin fibers or through the use of 3D-printing, [21,22].…”

“…Ideally, elastography-dedicated TMP are expected to offer the following features: (1) Their mechanical properties (such as elasticity, viscosity, anisotropy, porosity or hyperelasticity) must be well controlled and must lie within typical values of soft tissues they are supposed to mimic; (2) They should offer particular ease of use in terms of storage conditions and durability; (3) They must be compatible with the medical imaging modality for which they have been developed. Several studies have proposed elastography TMP that display particular mechanical properties beyond linear elasticity, such as viscosity (Madsen et al, 2003;Hadj Henni et al, 2011;Nguyen et al, 2014), poroelasticity (Chaudhry et al, 2016), anisotropy (Namani et al, 2009;Qin et al, 2013;Aristizabal et al, 2014;Chatelin et al, 2014;Schmidt et al, 2016), hyperelasticity (Erkamp et al, 2004;Gennisson et al, 2007;Pavan et al, 2010), heterogeneity (Gao et al, 1995;Bishop et al, 2000;Plewes et al, 2000;Madsen et al, 2005;Green, Bilston and Sinkus, 2008;Mariappan et al, 2009) and TMP including dynamic flow pulsations (Kolipaka et al, 2009). Inclusion of anisotropy (Chatelin et al, 2014) or porosity could be suggested through the addition of fibrin fibers or through the use of 3D-printing, as proposed by several authors for TMP (Wan et al, 2014;Guidetti et al, 2019).…”

“…5,5,10,15,20,30,40,50,60,80, 100, 150, and 200 ms. Common relevant imaging parameters for both sequences are: matrix 192 x 192, field of view 340 mm × 340 mm, slice thickness 6 mm, bandwidth 789 Hz.px −1 .…”