A New Classification for Malignant Tumors Involving the Anterior Skull Base

Cantù, Giulio; Solero, C. L.; Mariani, Luigi; Mattavelli, Franco; Pizzi, Natalia; Licitra, Lisa

doi:10.1001/archotol.125.11.1252

Cited by 42 publications

(24 citation statements)

References 32 publications

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“…Series that include significant number of cases without cribriform plate involvement show an overall cure rate of about 60% to 70% 11,14,18,24,25 ; when there is intracranial invasion, survival drops to less than 30%. 4,11 Both recurrence rate (12% vs 60%) 26 and disease-free survival (82% vs 38%) 27 have improved after the use of craniofacial resection of the ethmoid compared with the precraniofacial era. However, it is not well established whether craniofacial resection of the ethmoid improves the outcome of patients with tumors that do not involve the bony structures of the anterior skull base.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic factors in sinonasal tumors involving the anterior skull base

et al. 2003

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Section: Discussionmentioning

confidence: 99%

“…The UICC classification system (edition published in 2002) 3 and the staging system proposed by Cantu et al 4 (INT system) ( Table 1) were used to validate the usefulness of both systems as prognostic factors in our series. According to the UICC-AJCC staging , 4 tumors were staged T2, 28 T3, 18 T4a, and 50 T4b.…”

Section: Methodsmentioning

confidence: 99%

Prognostic factors in sinonasal tumors involving the anterior skull base

et al. 2003

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Section: Classificationmentioning

confidence: 99%

Current advances in the basic research and clinical management of sinonasal inverted papilloma (Review)

Sauter

Matharu²,

Hörmann³

et al. 2007

Oncol Rep

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Abstract. Inverted papilloma (IP) is a benign sinonasal lesion that has a known propensity for recurrence, local aggressiveness and an association with transformation to squamous cell carcinoma. Due to the high rate of recurrence, association with malignancy and a tendency of multicentricity, the surgical approaches to treatment are controversial. Over the years there has been a slow evolution from aggressive (en bloc) resection by lateral rhinotomy to endoscopic techniques. This progress corresponds to the advances that have been made in endoscopic sinus surgery over the past 15 years. Technological advances have allowed the detection of sinonasal IP before its extension beyond the sinonasal region, thus enabling minimally invasive techniques to be used in the treatment of selected cases of IP. Differences in recurrence rates were not observed for endoscopic management as compared with lateral rhinotomy or sublabial degloving approaches. In terms of aetiology there is certain evidence that the presence of HPV in IP could be predictive of malignant transformation. Although IPs are monoclonal proliferations, they do not fit the profile of a prototypic precursor lesion. In contrast, an increased EGFR and TGF-· expression is associated with early events in IP carcinogenesis. Parameters such as hyperkeratosis, squamous epithelial hyperplasia and a high mitotic index are negative prognostic indicators, which could be useful in the future follow-up of patients with IP. Present literature should encourage us to recommend the use of a uniformly accepted staging system. The propensity for delayed recurrences and the maximal 13% incidence of malignant transformation mandates careful, long-term follow-up.

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“…There is still no widely accepted classification for carcinomas located in the sphenoid and frontal sinus. The practical, clinical and prognostic use of the T classification for tumors in this region is still discussed controversially, and alternative classifications have been proposed in the past few years [37]. For the maxillary sinus (ICD-O C31.0), the classification is as follows: T1 for tumors of the antral mucosa without infiltration or destruction of the bone; T2 for tumors with destruction of the bony structure, excluding the posterior wall and including an extension to the hard palate or the lower and middle nasal passage; T3 defines tumors infiltrating the posterior wall of the maxillary sinus, the subcutaneous tissue, the floor or the medial wall of the orbit or the ethmoid sinus, the infratemporal fossa or the pterygopalatine fossa; T4 tumors of the maxillary sinus infiltrate the skull base, the nasopharynx, the sphenoid or the frontal sinus.…”

Section: Classificationmentioning

confidence: 99%

Sinonasal Malignancy: What’s New?

Götte¹,

Hörmann²

2004

ORL

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Tumors of the nasal cavity are located at a complex anatomic site and show a huge histological diversity. Although dealing with a rare malignancy, the last decade has brought – besides new histological and clinical classifications – a variety of new insights into etiological agents, tumor biology and therapeutic concepts as well as valuable overviews of rare histological subtypes. This review tries to disentangle the different medical and scientific aspects of the most frequently encountered histological types of tumors in the nasal cavity and the paranasal sinuses. We concentrate on epidemiology, classification, etiology, cytogenetics and molecular genetics, outcome and prognosis as well as treatment modalities, as far as the past few years have brought considerable new insights. Our principal aim is to provide the clinician with important data from publications of the last decade.

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A New Classification for Malignant Tumors Involving the Anterior Skull Base

Abstract: We propose the use of our staging system by all those specialists in the field willing to validate the classification and possibly apply it for clinical and investigational purposes.

Cited by 42 publications

References 32 publications

Prognostic factors in sinonasal tumors involving the anterior skull base

Prognostic factors in sinonasal tumors involving the anterior skull base

Current advances in the basic research and clinical management of sinonasal inverted papilloma (Review)

Sinonasal Malignancy: What’s New?

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