Sinonasal Malignancy: What’s New?

Götte, Karl; Hörmann, K.

doi:10.1159/000077801

Cited by 28 publications

(21 citation statements)

References 83 publications

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“…Both benign and malignant sinonasal neoplasms reveal significant histological diversity [5] and a similar pattern was noted in the present study. However, the percentages of various lesions seen in the present study cannot be compared with lesions in patients of different socioeconomic status and varying ethnicities.…”

Section: Discussionsupporting

confidence: 86%

Fine Needle Aspiration Cytology in Lesions of the Nose, Nasal Cavity and Paranasal Sinuses

Gupta¹,

Kaur²,

Srinivasan³

et al. 2011

Acta Cytologica

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Objective: To assess the spectrum of lesions in the sinonasal region diagnosed on FNAC. Study Design: This is a retrospective audit of sinonasal lesions diagnosed on FNAC over a period of 12 years (1998–2009). Results: Out of a total of 79,851 FNACs, 158 (0.2%) were from the sinonasal region. FNAC was non-diagnostic in 20 (12.6%) cases. Infective/inflammatory lesions comprised of 30 (19%) cases including non-specific inflammation (19), fungal infection (7), tuberculosis (2), actinomycosis (1) and filariasis (1). Benign cysts (24; 15.2%) included epidermal inclusion cysts, mucocele and aneurysmal bone cyst. Benign bone tumors (4) comprised of giant cell tumor, fibrous dysplasia, chondroma, and osteoblastoma. Other benign tumors included lipoma (6), hemangioma (5), schwannoma (2), meningioma (1), pleomorphic adenoma (1), sebaceous adenoma (1) and other skin adnexal tumors (3). Malignant epithelial tumors (24; 15.2%) included squamous cell carcinoma (10), basal cell carcinoma (5), poorly differentiated carcinoma (4) and metastatic carcinoma (5). Two cases of chordoma and one case each of dermatofibrosarcoma pertuberance and hemangiopericytoma were seen. Sarcomas included sarcoma, not otherwise specified (4), rhabdomyosarcoma (3), osteosarcoma (2), chondrosarcoma (2), leiomyosarcoma (1), malignant fibrous histiocytoma (1), fibrosarcoma (1) and malignant peripheral nerve sheath tumor (1). There were cases of malignant small round cell tumor (11), non-Hodgkin lymphoma (3), plasmacytoma (2) and malignant melanoma (2). Conclusion: A variety of non-neoplastic and neoplastic conditions can involve the sinonasal region. FNAC is a reliable diagnostic procedure in a good number of cases, especially in the light of clinico-radiological data.

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Section: Discussionsupporting

confidence: 86%

Fine Needle Aspiration Cytology in Lesions of the Nose, Nasal Cavity and Paranasal Sinuses

Gupta¹,

Kaur²,

Srinivasan³

et al. 2011

Acta Cytologica

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“…Anatomically the sinonasal area is comprised of the maxillary sinus, the ethmoid sinus and the nasal cavity, with various mucosal subsites; the septum, the Xoor of the nasal cavity, the lateral wall and the vestibule. Among the various histopathological types, the most common diagnoses are squamous cell cancer, adenocarcinoma, melanoma, sarcoma and adenoid cystic carcinoma [1,2]. Due to the anatomical structures, most cases have symptoms only at an advanced stage, which naturally impairs the survival of these patients [3].…”

Section: Introductionmentioning

confidence: 99%

“…The improved survival was also detected in Denmark between the periods of 1982-1991 and 1995-2004 [5]. Recent studies have advocated multimodality treatment for at least advanced cases of sinonasal cancer, but some controversy still exists concerning the frequency of regional metastases and the implication of elective neck treatment [2,4,[6][7][8][9][10]. Many reports are based on single-institution case series, which hampers the comparability of data between diVerent studies due to possible variation and selection bias among patients in the centres participating in these studies.…”

Section: Introductionmentioning

confidence: 99%

A national series of 244 sinonasal cancers in Finland in 1990–2004

Koivunen

Mäkitie

Bäck

et al. 2011

Eur Arch Otorhinolaryngol

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Sinonasal cancer is still a somewhat controversial entity because most series are single-center studies. The aim of this study was to give more accurate and generalisable information about treatment of the neck and prognosis of sinonasal cancer. Retrospective, population-based, multicentre study. Altogether 244 patients diagnosed in 1990-2004 were evaluated. The 3- and 5-year disease-specific survival (DSS) rates after treatment with curative intent were 68 and 57%, respectively. Regional status at the time of the diagnosis (P < 0.001, log rank) and local recurrence (P = 0.02, log rank) during the follow-up had a statistically significant effect on DSS. Initially 13% of the patients were diagnosed with neck metastasis. The proportion of regional recurrences during the follow-up was 9%, but it did not have a statistically significant impact on DSS (P = 0.68, log rank). Histopathology had no statistically significant impact on survival in this material of 244 patients. In conclusion, routine elective neck treatment of all sinonasal cancer patients is not recommended, but the importance of the treatment of the primary location is emphasised.

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“…Occupational exposures not only to leather and wood dust but also to several chemicals such as nickel, arsenic, and formaldehyde have been implicated in the etiology of sinonasal SCC. [10][11][12] However, tobacco, a strong etiologic factor for the majority of head and neck squamous cell carcinomas (HNSCCs), does not play an important role in sinonasal SCC. 13,14 Until the present moment, genetic studies on sinonasal SCCs have demonstrated TP53 mutations and p53 overexpression in up to 56% of cases.…”

mentioning

confidence: 99%