2020
DOI: 10.1016/j.biopha.2019.109608
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A new compound Trichomicin exerts antitumor activity through STAT3 signaling inhibition

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Cited by 16 publications
(24 citation statements)
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“…Trichomicin, a compound with antitumor activity, has been reported to significantly induce apoptosis in HT29 cells, and reduced IL-6 expression and phosphorylation of Stat3 in our previous study (Zhu et al, 2020). Based on these findings, we evaluated the antitumor effects of Trichomicin against colon cancer in a colorectal tumor animal model, and evaluated the role IL-6 and TNFa in these effects.…”
Section: Introductionmentioning
confidence: 88%
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“…Trichomicin, a compound with antitumor activity, has been reported to significantly induce apoptosis in HT29 cells, and reduced IL-6 expression and phosphorylation of Stat3 in our previous study (Zhu et al, 2020). Based on these findings, we evaluated the antitumor effects of Trichomicin against colon cancer in a colorectal tumor animal model, and evaluated the role IL-6 and TNFa in these effects.…”
Section: Introductionmentioning
confidence: 88%
“…Cells were maintained in DMEM/F12 (CAFs), MEM (Caco-2), or RPMI 1640 (other cell lines) medium supplemented with 10% fetal bovine serum (FBS), 1% sodium pyruvate solution, and 1% penicillin/streptomycin (Gibco, Grand Island, NY, USA) in a 37°C, 5% CO 2 , fully humidified incubator. Trichomicin (1mM and 10mM, lab stock), PMA (10mM, Calbiochem, Darmstadt, GER), and BP-1-102 (5 mM, Selleck Chemicals, TX, USA) were dissolved in DMSO and were further diluted with medium (for cell assays) (Zhu et al, 2020). Interleukin 6 (10 mg/ml, Peprotech, NJ, USA), TNFa (10 mg/ml, Peprotech, NJ, USA), and lipopolysaccharide (LPS) (1 mg/ml, Calbiochem, Darmstadt, GER) were dissolved in PBS, passed through a 0.22-mm filter, then stored at -80°C (Zhu et al, 2020).…”
Section: Cell Lines Cell Culture and Reagentsmentioning
confidence: 99%
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“…The Fr.1 was subjected to a Sephadex LH-20 column eluted with CH 2 Cl 2 /MeOH (1:1, v/v) and detected by TLC to give two subfractions (Fr.1-1-Fr.1-2). The Fr.1-1 was further isolated by semi-preparative HPLC (Agilent 1100, Zorbax SB-C18, 5 µm, 250 × 9.4 mm inner diameter; 1.5 mL min −1 ; 254 nm; Agilent, PaloAlto, CA, USA) eluting with CH 3…”
Section: Extraction and Isolationmentioning
confidence: 99%