A New Coupling Component for Sulfanilamide Determination

Bratton, A. C.; Marshall, E. K.

doi:10.1016/s0021-9258(18)73708-3

Cited by 2,720 publications

(96 citation statements)

References 11 publications

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“…The amine content of test and calibrator samples was determined colorimetrically by the method of Bratton and Marshall. 19 Identi®cation of the products of the reaction: Reaction products were identi®ed by comparative high performance liquid chromatography (hplc) using authentic metabolites; nitroso-chloramphenicol (NO-CAP), CAP-amine and glutathionesulphinamido-chloramphenicol (GSONHCAP). GSONH-CAP was prepared using the method of Ascherl et al 20 from NO-CAP kindly supplied by Dr Davide Della Bella.…”

Section: Methodsmentioning

confidence: 99%

The role of nitro-reduction and nitric oxide in the toxicity of chloramphenicol

Holt

Bajoria

1999

Hum Exp Toxicol

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1 Recent work on the toxicology of chloramphenicol suggests that its propensity to cause damage to the blood forming organs may be related to its potential for nitro-reduction and the subsequent production of nitric oxide. 2 In this study both aerobic and anaerobic nitro-reduction of chloramphenicol by human foetal and neonatal liver results in the production of the amine derivative. However intermediates of the reaction nitroso-or glutathionesulphinamido-chloramphenicol could not be detected by hplc. 3 Perfusion of chloramphenicol through isolated lobules of human placentae caused a decrease in blood pressure at a time which coincided with a peak of nitric oxide production. However, although the pressure drop could be reversed by an inhibitor of nitric oxide synthetase, the nitric oxide profile remained the same. 4 These observations suggest that involvement of the para-nitro group of chloramphenicol could cause both hemotoxicity and hypotension in susceptible individuals.

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Section: Methodsmentioning

confidence: 99%

The role of nitro-reduction and nitric oxide in the toxicity of chloramphenicol

Holt

Bajoria

1999

Hum Exp Toxicol

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“…Incubations were carried out in open test tubes with shaking at 37" for about two hours. The reaction was stopped by the addition of 3.0 ml of 6.7 percent trichloroacetic acid and after centrifugation kynurenine was determined on 3.0 ml of the supernatant fluid by the BRATTON-MARSHALL (1939) procedure. The tubes were stored at 0" for 14 hours before determining the optical density at 560 mp in a Beckman Model DU spectrophotometer.…”

Section: Materials a N D Methodsmentioning

confidence: 99%

Studies on Tryptophan Pyrrolase in Drosophila Melanogaster

Kaufman

1962

Genetics

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“…Nitrite concentrations were determined via a modified version of the Griess reaction [58]. Samples were combined in the autoanalyser with a reagent mixture containing HCl (75 ml), sulfanilamide (5 g) and N-1-napthylethylenediame dihydrochloride (NED; 0.25 g) in 500 ml ultrapure water.…”

Section: Aqueous Sample Nitrogen Concentrationsmentioning

confidence: 99%

15N Tracing of the Partitioning and Transport of Nitrate Under Field Conditions

Charteris

2019

15N Tracing of Microbial Assimilation, Partitioning and Transport of Fertilisers in Grassland Soils

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A New Coupling Component for Sulfanilamide Determination

Cited by 2,720 publications

References 11 publications

The role of nitro-reduction and nitric oxide in the toxicity of chloramphenicol

The role of nitro-reduction and nitric oxide in the toxicity of chloramphenicol

Studies on Tryptophan Pyrrolase in Drosophila Melanogaster

15N Tracing of the Partitioning and Transport of Nitrate Under Field Conditions

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