A New Cytotoxic Tetrahydroxanthene-1,3(2H)-dione Derivative from Uvaria cordata and Structure Revision of Valderramenol A

Abstract

A new tetrahydroxanthene-1,3(2H)-dione derivative (1) was isolated from the leaves of Uvaria cordata collected in Viet Nam. Its structure was elucidated to be a mixture of four tautomers (1a-1d) by a combination of extensive spectroscopic analyses and the theoretical calculation of Gibbs free energies. Compound 1 exhibited moderate cytotoxicity against KB, LNCaP, Hep-G2, MKN-7, SW-480, HL-60, and SK-Mel-2 cancer cell lines with IC 50 values ranging from 25.92 ± 2.33 to 44.29 ± 4.36 μg/mL. In addition, the previously reported structure of valderramenol A has been revised to 1a/1b.

Virtual Screening and in Vitro Evaluation to Identify a Potential Xanthine Oxidase Inhibitor Isolated from Vietnamese Uvaria cordata

“…In our previous study, the information on eight natural compounds from U cordata was collected from previous literature. 18,19 Three-dimensional structures of these compounds were constructed and used for the docking process with target bovine XO. The 3D structure of the bovine XO enzyme (PDB ID: 3NRZ) was selected for virtual screening with three chains of 1222 amino acids named A: (Thr-2-Lys-165), B: (Pro-224-Gly-528), and C: (Asp-571-Lys-1326).…”

“…In addition, we have reported the cytotoxicity of these compounds. 18,19 The current trend is the development of functional foods derived from medicinal plants. Although U cordata has antiinflammatory properties and is frequently used in traditional medicine, there has been no study on its potential to develop into a supportive treatment for gout.…”