A New Deficiency Disease Produced by the Rigid Exclusion of Fat From the Diet

Burr, George O.; Burr, Mildred M.

doi:10.1016/s0021-9258(20)78281-5

Cited by 1,002 publications

(51 citation statements)

References 7 publications

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“…The relationship between low serum 25-hydroxyvitamin D levels and increased risk of various immune-related diseases and disorders has been observed, including psoriasis, type 1 diabetes, multiple sclerosis, rheumatoid arthritis, tuberculosis, sepsis, and respiratory tract infections, etc. (18)(19)(20)(21)(22). Omega-3 fatty acids are an important component of cell membranes and have antioxidant effects (23,24).…”

Section: Discussionmentioning

confidence: 99%

The effect of combined supplementation with vitamin D and omega-3 fatty acids on blood glucose and blood lipid levels in patients with gestational diabetes

Huang

Zhao

et al. 2021

Ann Palliat Med

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Background: To investigate the effects of vitamin D and omega-3 fatty acids on glucose and blood lipid metabolism in gestational diabetes (GDM) women.Methods: A total of 150 patients with GDM aged 18-40 who were admitted to our hospital from May 2019 to December 2020 were enrolled in this study. The subjects were divided into test and control groups according to whether they took vitamin D and omega-3 fatty acids. The test group took 40,000 IU of vitamin D and 8,000 mg of omega-3 fatty acids twice a day. Comparative analysis of the changes in blood glucose and blood lipid levels of the two groups of patients was performed after 6 weeks. The t-test was used to compare the differences between groups, and the chi-square test was used to assess percentage differences.Repeated measures variance was used to analyze the effects of vitamin D and omega-3 fatty acids on insulin metabolism markers and blood lipid profiles.Results: After adjusting for baseline age and weight, it was found that the fasting blood glucose (FBG), fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), triglycerides (TGs), total cholesterol, low-density lipoprotein (LDL), and very-low-density lipoprotein (VLDL) in the test group were decreased by 0.3±0.2 mmol/L, 1.0±0.6 uIU/mL, 0.2±0.1, 0.3±0.1 mmol/L, 0.5±0.2 mmol/L, 1.1± 0.4 mmol/L, and 0.03±0.01 mmol/L, respectively, while homeostasis model assessment of beta cell (HOMA-β) was increased by 0.4±0.1. Compared to the placebo group, the test group's FBG, insulin, HOMA-IR, TGs, total cholesterol, LDL, and VLDL were all significantly decreased, and HOMA-β was markedly improved.However, no notable statistical difference was observed in the change of high-density lipoprotein (HDL) (P>0.05).Conclusions: Combined supplementation with vitamin D and omega-3 fatty acids for 6 weeks in patients with GDM can effectively reduce blood sugar and blood lipids, improve HOMA-β and insulin resistance, and ultimately effectively improve the glucose and lipid metabolism of patients.

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Section: Discussionmentioning

confidence: 99%

The effect of combined supplementation with vitamin D and omega-3 fatty acids on blood glucose and blood lipid levels in patients with gestational diabetes

Huang

Zhao

et al. 2021

Ann Palliat Med

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“…17,31 Ringtail has been mainly reported in laboratory rats (Rattus norvegicus), occurring either as a spontaneous disease in preweaning animals 3,4,16,29,31 or as an experimentally induced condition in adults. 1,2,7,9 Spontaneous cases of ringtail have been also described in the whitetailed hamster (Mystromys albicaudatus) 26 and the pouched mouse (Saccostomus campestris). 5 With regard to laboratory mice (Mus musculus), spontaneous cases of ringtail are sporadically observed and commonly reported in textbooks and reviews dealing with pathology of laboratory animals.…”

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confidence: 99%

Pathologic and Environmental Studies Provide New Pathogenetic Insights Into Ringtail of Laboratory Mice

et al. 2014

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Ringtail is a pathologic condition of laboratory rodents characterized by annular constrictions of the tail. Traditionally, it is classified as an environmental disorder caused by low relative humidity, but other factors (temperature, dietary deficiencies, genetic susceptibility, and caging type) have also been proposed. Twenty litters of mice with ringtail lesions occurred from September 2010 to August 2013 in a facility located in the northern Italy. Mice were maintained under controlled environmental conditions and fed a standard diet. Retrospective analysis of environmental data (relative humidity, temperature) was carried out. Gross, histopathologic, scanning, and transmission electron microscopy examination of tails and limbs was performed. The incidence of ringtail was 0.075% (20/26 800) of all weaned litters over the 3-year period of examination. Temperature and relative humidity remained within accepted limits in all cases except one. We observed annular constrictions in tail, digits of pes, crus, and antebrachium in 116 (100.0%), 47 (40.5%), 11 (9.5%), and 2 (1.7%) of 116 affected mice, respectively. Histologic and ultrastructural examination revealed abnormal keratin desquamation and presence of a keratin ring encircling the tail, causing progressive strangulation of the growing tail with subsequent compression and ulceration of underlying soft tissues, resulting in circulatory changes (edema, hyperemia, thrombosis, hemorrhages), ischemic necrosis, and eventually auto-amputation distal to the constriction. On the basis of our findings, we suggest a disorder of cornification as the primary lesion of ringtail in mice. The cause of these cases, however, remained undetermined, even though traditional etiologic factors (relative humidity, temperature, diet, caging type) were reasonably excluded.

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Section: The History Of the Importance Of Fatty Acid In The Dietmentioning

confidence: 99%

“…A requirement for specific fatty acids in the diet was first described for growing rats by Burr and Burr [15]. It was shown that skin lesions and physiological symptoms of deficiency, including kidney damage and death, could be reversed by supplementing a diet with lard [15]. In further studies [16,17], the researchers found that linoleic (LA) and linolenic (LNA) acids contributed to decreased deficiency symptoms.…”

Section: The History Of the Importance Of Fatty Acid In The Dietmentioning

confidence: 99%

Role of Long Chain Fatty Acids in Developmental Programming in Ruminants

Roque-Jiménez

Rosa-Velázquez

Pinos-Rodríguez

et al. 2021

Animals

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Nutrition plays a critical role in developmental programs. These effects can be during gametogenesis, gestation, or early life. Omega-3 polyunsaturated fatty acids (PUFA) are essential for normal physiological functioning and for the health of humans and all domestic species. Recent studies have demonstrated the importance of n-3 PUFA in ruminant diets during gestation and its effects on pre-and postnatal offspring growth and health indices. In addition, different types of fatty acids have different metabolic functions, which affects the developmental program differently depending on when they are supplemented. This review provides a broad perspective of the effect of fatty acid supplementation on the developmental program in ruminants, highlighting the areas of a developmental program that are better known and the areas that more research may be needed.

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A New Deficiency Disease Produced by the Rigid Exclusion of Fat From the Diet

Cited by 1,002 publications

References 7 publications

The effect of combined supplementation with vitamin D and omega-3 fatty acids on blood glucose and blood lipid levels in patients with gestational diabetes

The effect of combined supplementation with vitamin D and omega-3 fatty acids on blood glucose and blood lipid levels in patients with gestational diabetes

Pathologic and Environmental Studies Provide New Pathogenetic Insights Into Ringtail of Laboratory Mice

Role of Long Chain Fatty Acids in Developmental Programming in Ruminants

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