A New Definition for Intracranial Compliance to Evaluate Adult Hydrocephalus After Shunting

Gholampour, Seifollah; Yamini, Bakhtiar; Droessler, Julie; Frim, David M.

doi:10.3389/fbioe.2022.900644

Cited by 23 publications

(27 citation statements)

References 72 publications

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“…Recently we showed that an important aspect of experimental assessment of hydrocephalic brain is the issue of the length of time that brain tissue is under elevated ICP 42 . This is a parameter that has been poorly studied.…”

Section: Introductionmentioning

confidence: 99%

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Long-term recovery behavior of brain tissue in hydrocephalus patients after shunting

Gholampour

Frim²,

Yamini³

2022

Commun Biol

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The unpredictable complexities in hydrocephalus shunt outcomes may be related to the recovery behavior of brain tissue after shunting. The simulated cerebrospinal fluid (CSF) velocity and intracranial pressure (ICP) over 15 months after shunting were validated by experimental data. The mean strain and creep of the brain had notable changes after shunting and their trends were monotonic. The highest stiffness of the hydrocephalic brain was in the first consolidation phase (between pre-shunting to 1 month after shunting). The viscous component overcame and damped the input load in the third consolidation phase (after the fifteenth month) and changes in brain volume were stopped. The long-intracranial elastance (long-IE) changed oscillatory after shunting and there was not a linear relationship between long-IE and ICP. We showed the long-term effect of the viscous component on brain recovery behavior of hydrocephalic brain. The results shed light on the brain recovery mechanism after shunting and the mechanisms for shunt failure.

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Section: Introductionmentioning

confidence: 99%

“…This is a parameter that has been poorly studied. Firstly, hydrocephalus is often not acute with many patients presenting having had raised ICP for extended periods of time 17 , 42 . To accurately model this, it would be important to have a model where increased pressure on the brain is maintained for a long time 42 .…”

Section: Introductionmentioning

confidence: 99%

Long-term recovery behavior of brain tissue in hydrocephalus patients after shunting

Gholampour

Frim²,

Yamini³

2022

Commun Biol

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“…Non-invasive monitoring of the intracranial fluid content, such as intracranial compliance using MRI, has become an emerging need for clinical use in various types of hydrocephalus [ 73 ]. In the previous paragraph ( Section 3.3 ), we discussed that the increased μs’ may be associated with brain edema [ 59 , 60 ].…”

Section: Discussionmentioning

confidence: 99%

Hemodynamics and Tissue Optical Properties in Bimodal Infarctions Induced by Middle Cerebral Artery Occlusion

Chen

Lin

et al. 2022

IJMS

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Various infarct sizes induced by middle cerebral artery occlusion (MCAO) generate inconsistent outcomes for stroke preclinical study. Monitoring cerebral hemodynamics may help to verify the outcome of MCAO. The aim of this study was to investigate the changes in brain tissue optical properties by frequency-domain near-infrared spectroscopy (FD-NIRS), and establish the relationship between cerebral hemodynamics and infarct variation in MCAO model. The rats were undergone transient MCAO using intraluminal filament. The optical properties and hemodynamics were measured by placing the FD-NIRS probes on the scalp of the head before, during, and at various time-courses after MCAO. Bimodal infarction severities were observed after the same 90-min MCAO condition. Significant decreases in concentrations of oxygenated hemoglobin ([HbO]) and total hemoglobin ([HbT]), tissue oxygenation saturation (StO2), absorption coefficient (μa) at 830 nm, and reduced scattering coefficient (μs’) at both 690 and 830 nm were detected during the occlusion in the severe infarction but not the mild one. Of note, the significant increases in [HbO], [HbT], StO2, and μa at both 690 and 830 nm were found on day 3; and increases in μs’ at both 690 and 830 nm were found on day 2 and day 3 after MCAO, respectively. The interhemispheric correlation coefficient (IHCC) was computed from low-frequency hemodynamic oscillation of both hemispheres. Lower IHCCs standing for interhemispheric desynchronizations were found in both mild and severe infarction during occlusion, and only in severe infarction after reperfusion. Our finding supports that sequential FD-NIRS parameters may associated with the severity of the infarction in MCAO model, and the consequent pathologies such as vascular dysfunction and brain edema. Further study is required to validate the potential use of FD-NIRS as a monitor for MCAO verification.

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“…Nevertheless, we envision that the data presented in this report on a more specific marker gene like TRPV4 and MAPT in NPH can significantly improve the prior cases reporting misdiagnosis of either AD or NPH ( Joseph et al, 2006 ; Joseph et al, 2008 ; Lee et al, 2010 ; Shimada et al, 2011 ). Biomechanical aspects of intracranial compliance ( Gholampour et al, 2022 ) should also be considered in the future as well for NPH and AD biomarker studies.…”

Section: Discussionmentioning

confidence: 99%

TRPV4 mRNA is elevated in the caudate nucleus with NPH but not in Alzheimer’s disease

et al. 2022

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Symptoms of normal pressure hydrocephalus (NPH) and Alzheimer’s disease (AD) are somewhat similar, and it is common to misdiagnose these two conditions. Although there are fluid markers detectable in humans with NPH and AD, determining which biomarker is optimal in representing genetic characteristics consistent throughout species is poorly understood. Here, we hypothesize that NPH can be differentiated from AD with mRNA biomarkers of unvaried proximity to telomeres. We examined human caudate nucleus tissue samples for the expression of transient receptor potential cation channel subfamily V member 4 (TRPV4) and amyloid precursor protein (APP). Using the genome data viewer, we analyzed the mutability of TRPV4 and other genes in mice, rats, and humans through matching nucleotides of six genes of interest and one house keeping gene with two factors associated with high mutation rate: 1) proximity to telomeres or 2) high adenine and thymine (A + T) content. We found that TRPV4 and microtubule associated protein tau (MAPT) mRNA were elevated in NPH. In AD, mRNA expression of TRPV4 was unaltered unlike APP and other genes. In mice, rats, and humans, the nucleotide size of TRPV4 did not vary, while in other genes, the sizes were inconsistent. Proximity to telomeres in TRPV4 was <50 Mb across species. Our analyses reveal that TRPV4 gene size and mutability are conserved across three species, suggesting that TRPV4 can be a potential link in the pathophysiology of chronic hydrocephalus in aged humans (>65 years) and laboratory rodents at comparable ages.

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A New Definition for Intracranial Compliance to Evaluate Adult Hydrocephalus After Shunting

Cited by 23 publications

References 72 publications

Long-term recovery behavior of brain tissue in hydrocephalus patients after shunting

Long-term recovery behavior of brain tissue in hydrocephalus patients after shunting

Hemodynamics and Tissue Optical Properties in Bimodal Infarctions Induced by Middle Cerebral Artery Occlusion

TRPV4 mRNA is elevated in the caudate nucleus with NPH but not in Alzheimer’s disease

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