A new disposable membrane oxygenator with integral heat exchange

Bramson, M.L.; Osborn, John J.; Main, F. Beachley; O’Brien, Mark F.; Wright, John S.; Gerbode, Frank

doi:10.1016/s0022-5223(19)33194-0

Cited by 91 publications

(23 citation statements)

References 4 publications

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“…PDMS thin films can be produced at less than 20 μm thickness and greatly surpass the low permeability of early polymer membranes , and modern fabrication techniques can reliably produce defect‐free membranes that minimize the risk of gas embolism . The stacked parallel plate blood channels used in the first clinical membrane oxygenators can now be reproduced using soft lithography to yield sub‐10 μm channel heights , significantly reducing plasma boundary layers. This approach allows for the use of shorter blood channel lengths with lower pressure drops and correspondingly decreased priming volume to more closely mimic the physiology of the native lungs.…”

Section: Resultsmentioning

confidence: 99%

“…. The blood channel was enveloped by 51 µm thick reinforced silicone sheets to form concentric gas and water chambers, which oxygenated and heated the blood, respectively . The surrounding water chamber had the added benefit of compressing the plates to control blood channel height without requiring adjustment of sweep gas pressure.…”

Section: Parallel Plate Optimizations and The Rise Of Clinical Ecmo: mentioning

confidence: 99%

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Evolution of Gas Permeable Membranes for Extracorporeal Membrane Oxygenation

Yeager

Roy

2017

Artificial Organs

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Gas permeable membranes are a vital component of extracorporeal membrane oxygenation systems. Over more than half a century, membrane fabrication and packaging technology have progressed to enable safer and longer duration use of respiratory life support. Current research efforts seek to improve membrane efficiency and hemocompatibility, with the aim of producing smaller and more robust systems for ambulatory use. This review explores past and present innovations in oxygenator technology, suggesting possible applications of state-of-the-art membrane fabrication methods to address shortcomings of earlier concepts.

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Section: Resultsmentioning

confidence: 99%

Section: Parallel Plate Optimizations and The Rise Of Clinical Ecmo: mentioning

confidence: 99%

Evolution of Gas Permeable Membranes for Extracorporeal Membrane Oxygenation

Yeager

Roy

2017

Artificial Organs

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“…Heart-lung bypass was performed with either a rotating disk22 or membrane oxygenator. 6 Patients were under the care of Dr. Frank Gerbode at the Pacific Medical Center, San Francisco. At the time the Soulier technic was used, Total calciums were assayed by EDTA titra-the priming solution was blood collected in heparin.…”

Section: Patients Undergoing Open Heart Surgerymentioning

confidence: 99%

Calcium Ion Activity During Rapid Exchange Transfusion with Citrated Blood

et al. 1971

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Measurement of ionized calcium levels by the technic of Soulier during massive transfusion of ACD blood supplemented with various quantities of calcium led to the apparently erroneous conclusion that ionized calcium levels would rise in the recipient when each unit was supplemented with 0.6 g CaCl2, the quantity which restores normal ionized calcium levels in vitro. Measurement of ionized calcium activity with the Orion electrode indicates that this ratio of CaCl2 will maintain an approximately normal ionized calcium level in dog recipients if it is infused simultaneously with the blood. Based on this information, it appears reasonable to assume that heparinized ACD blood, recalcified with 0.6 g CaCl2 per unit, may be used to prime the extracorporeal circuit for open heart surgery with the confidence that it will not alter the ionized calcium activity of the patient's blood. Addition of calcium to the circulation following administration of ACD blood causes a sharp rise and then a fall in the recipient's level of ionized calcium. Further studies in a variety of situations are required before final guidelines can be formulated for supplementation of ACD blood with calcium in massive transfusion.

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“…Subsequent advances in bioengineering, including the development of dimethylpolysiloxane (silicone rubber) membranes 13 , facilitated the development of oxygenators that could be used for days, rather than hours [14][15][16][17] . During the mid-late 1960s, Theodor Kolobow and Warren Zapol, from the National Heart Institute (later the National Heart, Lung, and Blood Institute), Bethesda, demonstrated prolonged survival of full-term lambs exposed to one week of venovenous (VV) ECMO 17 , and the successful employment of ECMO and parenteral nutrition to provide 55 hours of total extrauterine support to a premature lamb fetus suspended in a bath of synthetic amniotic fluid 18 .…”

Section: Cover Notementioning

confidence: 99%