A new exposure system for the in vitro detection of GHz field effects on neuronal networks

Koester, Philipp Julian; Sakowski, Jan; Baumann, Werner; Glock, Hans-Walter; Gimsa, Jan

doi:10.1016/j.bioelechem.2006.03.039

Cited by 19 publications

(22 citation statements)

References 9 publications

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“…The absorbed power measurement makes the determination of whole-body mean SAR trivial, and if the latter is assumed to be proportional to local SARs it can be used to adjust local SAR predictions obtained by simulation using a commercial FDTD program with a numerical phantom. As far as we know, this is the first time that standing waves have been used in studies of the biological effects of mobile communications radiation, in spite of their relevance to the use of mobile communications devices indoors [8].…”

Section: Discussionmentioning

confidence: 97%

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An Experimental Set-Up for Measurement of the Power Absorbed From 900 MHZ GSM Standing Waves by Small Animals, Illustrated by Application to Picrotoxin-Treated Rats

López-Martín¹,

Bregáins²,

Jorge-Barreiro³

et al. 2008

PIER

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Abstract-We describe an experimental set-up for exposure of small animals to radiofrequency standing waves that allows direct measurement of the power absorbed by the animal. Essentially, the setup consists of a metallic box containing an antenna and experimental animal immobilized in a methacrylate holder; a signal generator feeding the antenna; and a power meter. In addition, the box can also contain a video camera to record the animal's behaviour, and a receiving antenna (connected externally to a power meter and a spectrum analyser) to detect undesired (external) radiation and possible harmonics of the radiating system. The absorbed power measurement trivially allows calculation of whole-body mean SAR from the animal's weight; and assuming local SARs to be proportional to whole-body mean SAR, the latter can be used to adjust organ-specific SAR predictions obtained by simulation using a commercial FDTD program with a numerical phantom. The use of the system is illustrated by application to rats given subconvulsive doses of picrotoxin to induce a seizure-prone state analogous to epilepsy: levels of the neuronal activity marker c-Fos in the frontal and piriform cortex of picrotoxin-treated rats exposed to 900 MHz GSM radiation were twice as high as those of unexposed animals.

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Section: Discussionmentioning

confidence: 97%

“…Indoors, radiation in the high megahertz or low gigahertz bands is present as standing waves [8], and therefore it is reasonable to suggest that could have effects that are qualitatively or quantitatively different from those of travelling waves, due to the different nature of both electromagnetic signals.…”

Section: Introductionmentioning

confidence: 99%

An Experimental Set-Up for Measurement of the Power Absorbed From 900 MHZ GSM Standing Waves by Small Animals, Illustrated by Application to Picrotoxin-Treated Rats

López-Martín¹,

Bregáins²,

Jorge-Barreiro³

et al. 2008

PIER

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show abstract

“…These systems are well adapted for cells or tissues contained in a Petri dish. For studies of neural networks, an exposure system for micro-electrode arrays (MEA) was developed by positioning this device in a waveguide [11]. In this case, neurons were cultured on electrodes at the bottom of the MEA, which allowed the extracellular recording of neuronal activity.…”

Section: Introductionmentioning

confidence: 99%

Setup for Simultaneous Microwave Heating and Real-Time Spectrofluorometric Measurements in Biological Systems

Kohler¹,

Ticaud²,

Iordache³

et al. 2014

PIER

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Abstract-In this paper, a delivery system allowing simultaneous microwave heating and real-time spectrofluorometric measurements in biological systems is proposed and characterized. This system is used to investigate the phase behavior of lipid bilayers from about 15 • C to 45 • C. The delivery system is based on an open transverse electromagnetic (TEM) cell combined with a spectrofluorometer via an optical cable system. A numerical and experimental dosimetry of the delivery system is conducted. The Specific Absorption Rate (SAR) efficiency of the system is 26.1 ± 2.1 W/kg/W. Spectrofluorometric measurements on Laurdan labeled small unilamellar vesicles (SUVs) are carried out. Generalized polarization (GP) of the SUV's membrane is obtained from the fluorescence intensities measured at two emission wavelengths.

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“…The most used experimental samples are excitable cells and tissues since they are likely to be sensitive to EM stimulation and to display reversible effects. They include single neuronal cells Platano et al, 2006;Marchionni et el., 2005;Paffi et al, 2007), neuronal networks (Tattersall et al, 2001;Pakhomov et al, 2003;Koester et al, 2007;Merla et al, 2011), inner ear hair cells of the organ of Corti (El Ouardi et al, 2011), and muscles, both skeletal (Lambrecht et al, 2006) and cardiac (Pakhomov et al, 2000). The observables are mostly electrophysiological parameters, such as the ionic current and the membrane voltage at the level of single cell, or the field potential generated by a group of interconnected neuronal cells.…”

Section: The Concept Of Real-time Acquisitions In Bioelectromagnetic mentioning

confidence: 99%

“…(Linz et al, 1999); (Pakhomov et al, 2000); (Lambrecht et al, 2006); (Koester et al, 2007). Parallel plates (Tattersall et al, 2001).…”

Section: Real-time Propagatingmentioning

confidence: 99%

Real Time Radio Frequency Exposure for Bio-Physical Data Acquisition

Paffi¹,

Apollonio²,

D’Inzeo³

et al. 2012

Real-Time Systems, Architecture, Scheduling, and Application

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A new exposure system for the in vitro detection of GHz field effects on neuronal networks

Cited by 19 publications

References 9 publications

An Experimental Set-Up for Measurement of the Power Absorbed From 900 MHZ GSM Standing Waves by Small Animals, Illustrated by Application to Picrotoxin-Treated Rats

An Experimental Set-Up for Measurement of the Power Absorbed From 900 MHZ GSM Standing Waves by Small Animals, Illustrated by Application to Picrotoxin-Treated Rats

Setup for Simultaneous Microwave Heating and Real-Time Spectrofluorometric Measurements in Biological Systems

Real Time Radio Frequency Exposure for Bio-Physical Data Acquisition

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