A New Family of Antibiotics: The Demethyltetracyclines

McCormick, J. R. D.; Sjolander, Newell O.; Hirsch, Ursula; Jensen, Elmer R.; Doerschuk, Albert P.

doi:10.1021/ja01573a089

Cited by 135 publications

(29 citation statements)

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“…These results were reminiscent of many reports in the literature (e.g. WELCH et al, 1954;REEDY et al, 195 5;McCoRMICK et al, 1957 andGARROD and WATERWORTH, 1960;KIRBY et al, 1961) that the chlorinated tetracyclines are 2-:~ times as potent against several species of bacteria as are TC or OTC. Moreover, the activity of dedimethylamino-OTC (DDA-OTC) which was about 10% as active as TC in inhibiting growth of E. coli, was also reflected in the cell-free system, in which 10 !Lgfml of DDA-OTC was required to inhibit to the same extent as 1 !LgfmlofTC (LASKIN and CHAN, 1964).…”

Section: Protein Synthesissupporting

confidence: 76%

“…It should be noted that although the tetracyclines have in general very similar antimicrobial spectra (DEL LovE et al, 1954;BoHONOS et al, 1953), there have been reported some significant quantitative differences. Thus, the chlorinated compounds, chlortetracycline and demethylchlortetracycline, were found to be considerably more active than oxytetracycline and tetracycline against a variety of staphylococci, streptococci and pneumococci REEDY et al, 1955;McCORMICK et al, 1957 andGARROD and WATERWORTH, 1960) and coliforms (KIRBY et al, 1961).…”

Section: Allen I Laskinmentioning

confidence: 99%

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Antibiotics

1967

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AII rights, especially that of tnmslation into foreign languages, reserved. It is also forbidden to reproduce this book, either whole DedicationFor most areas of scientific pursuit, there is usually that rare investigator who has the imagination to conceive ideas, who has faith in his visions, and who has the ability to critically test his concepts in the laboratory. Almost invariably, this scientist also inspires younger men to enthusiastically enter into his research program. To him should go the accolades and the recognitions of the esteem in which he is held. As only a small part of this esteem, we wish to dedicate these books to Professor SELMAN A. W AKSMAN in appreciation of his leadership and contributions in all facets of antibiotic research. PrefaceThe idea for publishing these books on the mechanism of action and on the biosynthesis of antibiotics was born of frustration in our attempts to keep abreast of the literature. Gone were the years when we were able to keep a bibliography on antibiotics and feel confident that we could find everything that was being published on this subject. These fields of investigation were moving forward so rapidly and were encompassing so wide a range of specialized areas in microbiology and chemistry that it was almost impossible to keep abreast of developments. In our naivete and enthusiasm, however, we were unaware that we were toying with an idea that might enmesh us, that we were creating an entity with a life of its own, that we were letting loose a Golom who instead of being our servant would be our master.That we set up ideals for these books is obvious; they would be current guides to developments and information in the areas of mechanism of action and biosynthesis of antibiotics. For almost every subject, we wished to enlist the aid of an investigator who himself had played a part in determining the nature of the phenomena that were being discussed. One concept for the books was that they include only antibiotics for which a definitive, well-documented mechanism of action or biosynthetic pathway was known. Yet, such an approach would not entirely serve the purpose we projected, for it would not encompass all of the information available in these fields of antibiotic investigations and blind searches for the original literature would still have to be made. We therefore chose to include any and all antibiotics about which some pertinent information had been published. It was obvious even at the start that such a compilation, integration, and analysis of information could never be complete unless scientific investigations ceased at the moment the last manuscript was submitted-an end that was neither desirable nor possible. An addendum was therefore included at the end of the volume and left open for the addition of new information until the last pages of the regular articles had been printed.The original concept has also been further expanded as the authors of several papers found it advisable to elaborate on their subject. Some of the articles included discussions...

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Section: Protein Synthesissupporting

confidence: 76%

Section: Allen I Laskinmentioning

confidence: 99%

Antibiotics

1967

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“…Pro,perties of Demethylchlortetracycline In 1957 McCormick et al '8 described a new family of tetracyclines characterized by the absence of a CH. group which is found in all others.…”

mentioning

confidence: 99%

Demethylchlortetracycline

Finland¹,

Garrod²

1960

BMJ

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“…This was fi rst discovered by Kelner in 1949 [51] but the more active derivatives were not isolated and identifi ed. However, the medically useful metabolites demethyltetracycline [52] and doxorubicin [53] were discovered later by mutation of the cultures producing tetracycline and daunomycin, respectively. In 1969, the technique of " mutational biosynthesis " (= mutasynthesis) was devised by University of Illinois Professors Kenneth Rinehart and David Gottlieb and student W.T.…”

Section: Strain Improvementmentioning

confidence: 99%

History of Industrial Biotechnology

Demain

2010

Industrial Biotechnology

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A New Family of Antibiotics: The Demethyltetracyclines

Cited by 135 publications

References 2 publications

Antibiotics

Antibiotics

Demethylchlortetracycline

History of Industrial Biotechnology

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