A new fatty ester and a new triterpene fromSkimmia laureola

Abstract

Aerial parts of Skimmia laureola yielded a new fatty ester, (+)-skimmilaureol (1), and a new triterpene 16-29-dihydroxy, 20-ene cyclolaudenol (2). Five known compounds, namely, O-methyl-cyclolaudenol (3), (R)-7-methoxy-6-(3'-hydroxy-2'R-methoxy-3'-methyl butyl)coumarin (4), (+)-(S)-psi-ribalinine (5), (R)-(+)-ribalinine (6) and methyl isoplatydesmine (7), previously isolated from this plant were subjected to enzymatic bioassays for the first time. Compounds 3 and 4 were found to be prolyl endopeptidase inhibitors with IC(50) 8.21 +/- 0.407 and 39.63 +/- 1.502 microM, respectively, while compounds 5-7 were found to be acetyl-cholinesterase and butyryl-cholinesterase inhibitors with IC(50) 62.46 +/- 1.58, 153.31 +/- 1.9, 74.5 +/- 1.05 and 150.04 +/- 0.45, 12.99 +/- 0.31, 78.3 +/- 1.86 microM, respectively.

A New Lanostane Triterpene from Skimmia laureola

“…Methyl cyclolaudenol and (R)-7-methoxy-6-(3 -hydroxy-2 R-methoxy-0932-0776 / 09 / 0400-0459 $ 06.00 c 2009 Verlag der Zeitschrift für Naturforschung, Tübingen · http://znaturforsch.com 3 -methyl-butyl)coumarin were found to be prolyl endopeptidase inhibitors with IC 50 = 8.21 ± 0.407 and 39.63 ± 1.502 µ M, respectively, while ψ-ribalinine, (R)-(+)-ribalinine and methyl isoplatydesmine, were found to be acetyl-cholinesterase and butyryl-cholinesterase inhibitors with IC 50 = 62.46 ± 1.58, 153.31 ± 1.9, 74.5 ± 1.05 and 150.04 ± 0.45, 12.99 ± 0.31, 78.3 ± 1.86 µ M, respectively [19].…”

Lipoxygenase inhibition by novel fatty acid ester fromAnnona squamosaseeds

“…The crude alcoholic extract of Annona squamosa exhibited lipoxygenase activity [14,15,16]. The crude ethanolic extract of fruit pulp and seeds of Annona squamosa exhibited lipoxygenase activity with 22.2 and 26.7% inhibition, respectively at a concentration of 40 mg/200 mL, while the pet.ether extract of seeds of A. Squamosa exhibited 52.7% inhibition at the same concentration ( Table -II).…”

Phytochemical analysis of chloroform extract of leaves of Skimmia laureola

“…S. laureola is a strongly scented, evergreen, glabrous shrub, distributed in Northern India and China 1 . From S. laureola fatty ester, terpenoids and quinoline alkaloids have been isolated [11][12][13] . In the present study the phytochemical analysis of chloroform extract of air dried leaves of S. laureola was carried out using CC over Si-gel using various solvents afforded β-stosterol (1), (E)-3'-(4-Hydroxyphenyl)-2'-propenoic methyl ester (2), (E)-3'-(4-Hydroxy-3-methoxyphenyl)-2'-propenoic methyl ester (3), and bergapten (4).…”