A new flavonol glycoside and biological activities ofAdenanthera pavoninaL. leaves

Abstract

Adenanthera pavonina is a plant belonging to family Fabaceae. The 95% ethanol extract (EtOH) of the dried powdered leaves of the plant and successive extracts with solvents of increasing polarities were prepared. Fractionation of the successive aqueous EtOH extract on polyamide column and purification of the isolated compounds on Sephadex LH20 led to the isolation of a new methoxy flavonol glycoside named as quercetin 3-O-α-dirhamnopyranosyl-(1‴ → 2″,1″″ → 6″)-β-glucopyranoside-4'-methoxy (1), as well as kaempferol-3-O-α-dirhamnopyranosyl-(1‴ → 2″,1″″ → 6″)-β-glucopyranoside (2), isovitexin (3), quercetin-3-O-rhamnopyranosyl(1‴ → 4″)-β-glucopyranoside (4), quercetin-3-O-β-glucopranoside-4'-O-rhamnopyranoside (5), kaempferol-3-O-α-rhamnopyranosyl(1‴ → 2″)-β-glucopyranoside (6), quercetin-3-O-rhamnopyranosyl(1‴ → 2″)-β-glucopyranoside (7), quercetin-3-O-β-glucopyranoside (8), kaempferol (9) and quercetin (10). Structures of the isolated compounds were established by spectroscopic analysis. Antioxidant activities of EtOH extract, successive extracts and compounds 1 and 2 were evaluated. The ethyl acetate (EtOAc) extract and EtOH extract showed 62.67% and 49.30% free radical scavenging activity, respectively. Cytotoxic activities of the EtOH extract and compounds (1) and (2) were evaluated. The EtOH extract showed a significant cytotoxic activity against Hep G-2 (IC50 = 2.50 μg) as compared with cisplatin (IC50>10 μg).

Scabiosa stellata L. Phenolic Content Clarifies Its Antioxidant Activity

“…The presence of the 13 C-NMR characteristic signals ( Table S1 ) also proves that the aglycone is tamarixetin; moreover, these results are in accordance with the previous data [ 37 ]. The glycoside residue was also established, with the presence of three doublets at δ 5.75, 5.21 and 4.56 ppm, characteristic signals of anomeric protons, indicative of the three hexoses.…”

“…In the case of the peak eluted at 20.94 min, the confirmation was also established because this tamarixetin glycoside 13 ( Figure 1 ) was isolated and fully characterized. At first glance, this compound seems to be an unusual tamarixetin derivative, whose occurrence in nature was recently reported and not in the Scabiosa genus [ 37 ]. Therefore, to confirm the identification its characterization was meticulous and compared with the previous reported data and accordingly the compound was identified as being the tamarixetin 3-β- l -rhamnosyl-(1→2)β- l -rhamnosyl-(1→6)]β- d -glucoside] 13 ( Figure 1 ).…”

Production of a New Plant-Based Milk from Adenanthera pavonina Seed and Evaluation of Its Nutritional and Health Benefits

“…Stigasterol and its glucoside, dulcitol, and a polysaccharide are also present in the kernel ( 30 – 32 ). The presence of isovitexin, β-glucopyranoside, kaempferol, and quercetin also contribute to the bioactivity of A. pavonina ( 33 ). There was no report on A. pavonina serving as source of milk.…”

Evaluation of anticancer properties of a decoction containing Adenanthera pavonina L. and Thespesia populnea L.

“…The decoction used in the present study contains Adenanthera pavonina L. and Thespesia populnea L. Both of these plants have numerous medicinal applications. Some of them include the anti-diabetic, anti-hyperlipidemic activity [ 5 ], antinociceptive, anti-inflammatory effects [ 6 ], antibacterial activity [ 7 ] and pharmacological effects related to Alzheimer’s disease [ 8 ] by Thespesia populnea L. Similarly, Adenanthera pavonina L. contains anti-inflammatory [ 9 , 10 ], anti-bacterial [ 11 ], anti-hyperglycemic, lipid reducing potential [ 12 ] antioxidant and cytotoxicity properties [ 13 ]. A decoction prepared in combination with these two plants, Adenanthera pavonina L. and Thespesia populnea L. has been used for years to cure cancer patients by indigenous practitioners.…”