A New Furanocoumarin Glycoside from the Roots of Ficus hirta

Dai, Tran Duc; Tâm, Nguyễn Thành; Thiện, Đào Đức; Hoàng, Nguyễn Huy; Thủy, Trịnh Thị; Anh, Nguyễn Thị Hoàng; Quân, Trần Đức

doi:10.2174/1570178615666180329155025

Cited by 11 publications

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“…Certain studies regarding the chemical composition and pharmacological activities of F. hirta Vahl. reported that benzene derivatives, phenolics, and glycosides of flavonoid are majorly present in this plant [2,5,11,12]. Recently, three new monosubstituted benzene derivatives elucidated as (2R) methyl 2-O-β-d-glucopyranosyl-2-phenyl acetate, (2S) 2-O-benzoyl-butanedioic acid-4-methyl ester, and 4-O-benzoyl-quinic acid were initially isolated from the ethanolic extracts of HFF by our group members [8], and one new compound depicted a potent antifungal effect against Penicillium italicum isolated from citrus fruits.…”

Section: Introductionmentioning

confidence: 94%

“…Furthermore, pinocembrin-7-O-β-D-glucoside (13), the main antifungal flavonoid, was also detected in CE of HFF. Two carboline alkaloids (1 and 2) were all detected in polar extracts (AE, ME, WE), while sesquiterpenoids/norsesquiterpenoids (3)(4)(5)(6) and monosubstituted benzene derivatives (7)(8)(9)(10)(11)(12) were detected in most HFF extracts, except PEE. Only three compounds were detected in PEE extract, notably, umbelliferone (18) was only detected in CE extract.…”

Section: Hplc-qtof-ms Analysis Of Hff Extractsmentioning

confidence: 99%

“…Furthermore, 5-O-[β-d -apiofuranosyl-(1→2)-β-d-glucopyranosyl]-bergaptol was the first ever reported furanocoumarin glycoside extracted from the roots of F. hirta Vahl. [12]. Several studies also claimed an anti-inflammatory activity of the root extracts of F. hirta Vahl., and phenylpropanoids, bergapten, lupeol palmitate, and azelaic acid were responsible for the anti-inflammatory activity [4,14,15].…”

Section: Introductionmentioning

confidence: 98%

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Antioxidant, Antifungal Activities of Ethnobotanical Ficus hirta Vahl. and Analysis of Main Constituents by HPLC-MS

et al. 2020

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The medicinal and edible plant, Ficus hirta Vahl. (also called hairy fig), is used for the treatment of constipation, inflammation, postpartum hypogalactia, tumors, and cancer. There is an urgent need for scientific evaluation to verify the pharmacological properties of F. hirta. Therefore, in vitro assays evaluated the antioxidant and antifungal activities of various solvent extracts of hairy fig fruits (HFF). HFF extracts had abundant antioxidant components for a significant amount of total phenolic (TPC) and flavonoid contents (TFC) (TPC from 17.75 ± 0.52 to 85.25 ± 1.72 mg gallic acid/g dw and TFC from 15.80 ± 0.59 to 144.22 ± 8.46 mg rutin/g dw, respectively). The ethyl acetate extract (EAE) and acetone extract (AE) of HFF demonstrated potent antioxidant activities against 1,1-diphenyl-2-picrylhydrazyl (DPPH) (IC50 values of 2.52 and 2.02 mg/mL, respectively) and ABTS radicals (IC50 values of 3.06 and 9.26 mg/mL, respectively). Moreover, the AE with a high TFC showed a prominent in vitro and in vivo antifungal activity against Penicillium italicum, causing citrus blue mold. Eighteen metabolites were identified or putatively identified from six HFF extracts. Current findings indicated that HFF extracts had significant antioxidant and antifungal activities and could potentially be used as an alternative agent for the preservation of agricultural products.

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Section: Introductionmentioning

confidence: 94%

Section: Hplc-qtof-ms Analysis Of Hff Extractsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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Antioxidant, Antifungal Activities of Ethnobotanical Ficus hirta Vahl. and Analysis of Main Constituents by HPLC-MS

et al. 2020

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“…Phytochemical investigations on the genus Ficus have revealed flavonoids (especially isoflavones) [14][15][16][17][18] and terpenoids [19][20][21][22][23][24][25] as the major chemical constituents. Phytochemicals such as alkaloids [26][27][28], coumarins [29][30][31], and phenolic acids [32,33] have also been reported from various species of Ficus. However, the systematic phytochemical studies of F. thonningii from East Africa has hitherto not been reported.…”

Section: Introductionmentioning

confidence: 99%

Chemical Constituents from the Stem Bark of Ficus thonningii and their Chemotaxonomic Significance

Ibrahim

Omosa

Onyari

et al. 2022

EJMP

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Background of the Study: Tropical plants of the Ficus genus (Moraceae) are among the earliest fruit trees that humans have cultivated. Since ancient times, many folk medicines have used species of this genus to treat a variety of ailments. Evidence from earlier investigations has shown these plants contain abundant secondary metabolites with a variety of structural properties and biological functions. Place and Duration of Study: The research was carried out at the University of Nairobi (Faculty of Science and Technology, Department of Chemistry) from January to June 2022. Aim: The study focuses on isolating and identifying secondary metabolites from the stem bark of Ficus thonningii Blume found in Kenya and their chemotaxonomic significance. Methodology: Dried powdered stem bark of Ficus thonningii was extracted by maceration at room temperature using CH2Cl2/CH3OH (1:1) to yield a crude extract which was fractionated in a chromatographic column (CC) using silica gel (60 – 120 mesh) as an adsorbent eluting with EtOAc/n-hexane followed by CH3OH/EtOAc. The fractions were purified using silica gel (70 – 230, 230 – 400 mesh) CC and chromatotron eluting with solvents of different polarity, as well as a crystallization technique. Structures of the isolated compounds were elucidated and identified using the spectroscopic method (NMR (1D and 2D)) and by comparison with reported literature data. Results: Phytochemical investigation of the stem bark of Ficus thonningii afforded seven compounds, including yukovanol (1), 5,7,4′-trihydroxy-3′-(2-hydroxy-3-methyl-3-butenyl)isoflavone (2), cajanin (3), taxifolin (4), protocatechuic acid (5), saccharose (6), and stigmasterol (7). Compounds 1 - 3, 5 and 7 were not reported from F. thonningii until now. Further, compound 6 is being isolated from the genus Ficus for the first time. Conclusion: The chemotaxonomic significance of the isolated phytochemicals demonstrates the taxonomic position of F. thonningii in the genus Ficus and explains its multiple ethnomedicinal applications.

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“…Dao Duc Thien et al have separated and analyzed the chemical components in the extract of F. hirta. The result has identified a new 5-O-[β-D-apiofuranosyl-(1→2)-β-D-glucopyranosyl] bergaptol (1), 9 known compounds [10,11] from the Roots of F. hirta and 04 triterpenoid with a new 3β-hydroxy-11-oxo-olean-12-enyl-3-stearate [12] from leaves of F. hirta. This paper reports the isolation and structure identification of two triterpenoids, α-amyrin acetate (1), 3β-acetoxy-11α-hydroxy-12-ursenes (2) and two phenolics, p-coumaric acid (3), isovitexin (4) from leaves of F. hirta collected in Yen Son district, Tuyen Quang province, Vietnam.…”

Section: Introductionmentioning

confidence: 99%

Triterpenoids and Phenolics from the Leaves of Ficus hirta Vahl. in Tuyen Quang Province, Vietnam

Dai¹,

Tâm²,

Huong³

et al. 2020

IJFSA

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A New Furanocoumarin Glycoside from the Roots of Ficus hirta

Cited by 11 publications

References 0 publications

Antioxidant, Antifungal Activities of Ethnobotanical Ficus hirta Vahl. and Analysis of Main Constituents by HPLC-MS

Antioxidant, Antifungal Activities of Ethnobotanical Ficus hirta Vahl. and Analysis of Main Constituents by HPLC-MS

Chemical Constituents from the Stem Bark of Ficus thonningii and their Chemotaxonomic Significance

Triterpenoids and Phenolics from the Leaves of Ficus hirta Vahl. in Tuyen Quang Province, Vietnam

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