A new generation of star polymer: magnetic aromatic polyamides with unique microscopic flower morphology and in vitro hyperthermia of cancer therapy

Eivazzadeh‐Keihan, Reza; Radinekiyan, Fateme; Maleki, Ali; Bani, Milad Salimi; Azizi, Mojtaba

doi:10.1007/s10853-019-04005-6

Cited by 72 publications

(26 citation statements)

References 52 publications

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“…3 So far, a diverse range of non-natural and natural-based polymers with different applications such as catalysis with high yield efficiency [4][5][6] and adsorption of heavy metal ions 7 have been applied. On the other hand, different biomedical approaches such as tissue engineering, 8,9 drug delivery systems, [10][11][12] hyperthermia cancer therapy, 13,14 and wound healing 15,16 have been exclusively developed by using these types of material. Also, the formation of polymer-based nanomaterials as new biosensing probes has led to advanced detection of pathogenic viruses, 17,18 toxic mycotoxins, 19 neurotoxic proteins, 20 and cancer biomarkers.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the biological activity, mechanical properties and wound healing application of a novel scaffold based on lignin–agarose hydrogel and silk fibroin embedded zinc chromite nanoparticles

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Investigation of the biological activity, mechanical properties and wound healing application of a novel scaffold based on lignin–agarose hydrogel and silk fibroin embedded zinc chromite nanoparticles

et al. 2021

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“…So far, ZnFe 2 O 4 MNPs has been combined with variety of natural and synthetic polymers such as Chitosan 21 , Tragacanth gum 20 , Poly(vinylidene fluoride) 22 , Polydopamine 23 , polystyrene 24 , polyaniline 25 , polypyrrole 26 , poly(o-phenylenediamine) 27 , polythiophene 28 , polyvinyl pyrrolidone 29 , Poly(m-phenylenediamine) 30 , poly methyl methacrylate 31 for different purposes. In addition, there are various reports of different polymers growing during the polymerization process on the surface of MNPs to preparation novel magnetic star polymers 7 , 32 . In these types of polymers, MNPs act as core and magnetic star-shaped polymeric structures are obtained 7 , 32 .…”

Section: Introductionmentioning

confidence: 99%

“…In addition, there are various reports of different polymers growing during the polymerization process on the surface of MNPs to preparation novel magnetic star polymers 7 , 32 . In these types of polymers, MNPs act as core and magnetic star-shaped polymeric structures are obtained 7 , 32 .…”

Section: Introductionmentioning

confidence: 99%

Novel magnetic organic–inorganic hybrids based on aromatic polyamides and ZnFe2O4 nanoparticles with biological activity

Eivazzadeh‐Keihan

Gorab

Aliabadi

et al. 2021

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Magnetic nanoparticles were creatively selected as stable, inexpensive, biodegradable, facile recoverable, and functionalizable supports for a variety of synthetic and natural polymers. Herein, for the first time, aromatic polyamide was synthesized on the magnetic core of zinc iron oxide (ZnFe2O4). Terephthaloyl chloride and derivations of phenylenediamine were employed as monomers in this polymerization process. The toxicity of the synthesized hybrid at the highest concentration (1000 μg/ml) is 13.65% and on the other hand, the cell viability percentage is 86.35%. So, the prepared hybrid is biocompatible and non-toxic to Hu02 cells. Also, it has antibacterial ability against gram-positive and gram-negative bacteria. Because the results show that the minimum inhibitory concentration (MIC) of the synthesized polymer for bacteria such as Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Pseudomonas aeruginosa ATCC 27853 is in the range of 500–1000 µg/ml. Moreover, the hemolytic effect of ZnFe2O4 based hybrid was below 9% at the concentration of 1000 μg/ml. Therefore, it is compatible with red blood cells.

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“…5 b). Considering reported literatures about surface modification of Fe 3 O 4 MNPs and formation of various magnetic-based nanocomposites, it has been clarified that the contribution and immobilization process of non-magnetic shells on the surface of Fe 3 O 4 cores can reduce their saturation magnetization value 52 , 53 . Therefore, it can be deduced that the observed reduction in saturation value of Fe 3 O 4 @SiO 2 @CPTMS@DA nanocomposite (20.77 emu/g) is related to the surface functionalization of Fe 3 O 4 MNPs using inorganic and organic shells.…”

Section: Resultsmentioning

confidence: 99%

Design and synthesis of a novel nanocomposite based on magnetic dopamine nanoparticles for purification of α-amylase from the bovine milk

Eivazzadeh‐Keihan

Dogari

Ahmadpour

et al. 2021

Sci Rep

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In this paper, a novel nanocomposite based on magnetic nanoparticles decorated by dopamine were reported. Three modified magnetic nanocomposites by dopamine were offered with different type of linkers. The mentioned magnetic nanocomposites were applied to separate α-amylase protein from fresh bovine milk. All of the magnetic nanocomposites were characterized and investigated by using Fourier-transform infrared spectroscopy, energy-dispersive X-ray spectroscopy, field-emission scanning microscope, X-ray diffraction pattern, and vibrating-sample magnetometer analyses. To investigate the purifying application, sodium dodecyl sulfate polyacrylamide gel electrophoresis, one-dimensional isoelectric focusing gel electrophoresis, and alpha-amylase activity assay were employed. With paying attention to factors such as yield of purification and concentration of separated protein by each of magnetic nanocomposite, it could be concluded that the length of linkers played an important role in α-amylase protein separation. According to the results, the best separation and purification of α-amylase protein with 49.83% recovery and 40.11-fold purification efficiency was related to longest length linker, 1,4-butanediol diglycidyl ether, because of considerable conjugation with nanocomposite. Also, docking calculation has shown that the binding energy is − 1.697 kcal/mol and ΔG = − 6.844 kcal/mol which result that the interaction process between dopamine and α-amylase protein is spontaneous.

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A new generation of star polymer: magnetic aromatic polyamides with unique microscopic flower morphology and in vitro hyperthermia of cancer therapy

Cited by 72 publications

References 52 publications

Investigation of the biological activity, mechanical properties and wound healing application of a novel scaffold based on lignin–agarose hydrogel and silk fibroin embedded zinc chromite nanoparticles

Investigation of the biological activity, mechanical properties and wound healing application of a novel scaffold based on lignin–agarose hydrogel and silk fibroin embedded zinc chromite nanoparticles

Novel magnetic organic–inorganic hybrids based on aromatic polyamides and ZnFe2O4 nanoparticles with biological activity

Design and synthesis of a novel nanocomposite based on magnetic dopamine nanoparticles for purification of α-amylase from the bovine milk

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