Novel magnetic organic–inorganic hybrids based on aromatic polyamides and ZnFe2O4 nanoparticles with biological activity

Abstract

Magnetic nanoparticles were creatively selected as stable, inexpensive, biodegradable, facile recoverable, and functionalizable supports for a variety of synthetic and natural polymers. Herein, for the first time, aromatic polyamide was synthesized on the magnetic core of zinc iron oxide (ZnFe2O4). Terephthaloyl chloride and derivations of phenylenediamine were employed as monomers in this polymerization process. The toxicity of the synthesized hybrid at the highest concentration (1000 μg/ml) is 13.65% and on the other hand, the cell viability percentage is 86.35%. So, the prepared hybrid is biocompatible and non-toxic to Hu02 cells. Also, it has antibacterial ability against gram-positive and gram-negative bacteria. Because the results show that the minimum inhibitory concentration (MIC) of the synthesized polymer for bacteria such as Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Pseudomonas aeruginosa ATCC 27853 is in the range of 500–1000 µg/ml. Moreover, the hemolytic effect of ZnFe2O4 based hybrid was below 9% at the concentration of 1000 μg/ml. Therefore, it is compatible with red blood cells.

Decoration of graphene oxide nanosheets with carboxymethylcellulose hydrogel, silk fibroin and magnetic nanoparticles for biomedical and hyperthermia applications

“…According to previous studies, if magnetic nanoparticles are placed in a composite structure, their value of saturation magnetization will be reduced. 27,40 By comparing the saturation magnetization of pure Fe 3 O 4 (which is about 75 emu g −1 ) 27 and the nanobiocomposite (which is about 8.47 emu g −1 ), it can be concluded that magnetic nanoparticles are well placed in the structure of the composite.…”

A comprehensive review on the applications of carbon-based nanostructures in wound healing: from antibacterial aspects to cell growth stimulation

“…Therefore, the development of new antibacterial agents is still a hot research topic. 6,[17][18][19] Micro/ nanocarbon functional materials that can be used as carriers and antibacterial agents in the field of antibacterial dressings have attracted attention from medical staff and researchers. Because these micro/nanocarbons have many advantages including raw materials, low preparation cost, good mechanical stability, strong biocompatibility, biodegradability and antibacterial activity.…”

Facile preparation of a cost-effective platform based on ZnFe2O4 nanomaterials for electrochemical cell detection

“…The broad peak at 3384 cm −1 in the ZnFe 2 O 4 spectrum is attributed to the vibration stretching of the O–H groups of the water molecules adsorbed on the ZnFe 2 O 4 surface during the hydrothermal synthesis 45 . In addition, two vibration peaks at 1500 cm −1 and 1612 cm −1 are associated with O–H binding, suggesting a large number of hydroxyl groups on the surface of colloidal ZnFe 2 O 4 46 , 47 . The ZC exhibits some peaks at 835 cm −1 (aromatic CH=), 1191–1281 cm −1 (C=C bonds), and 2873 cm −1 (C–H groups).…”