A new gradient matrix: Formulation and characterization

Hildgen, Patrice; McMullen, J.N.

doi:10.1016/0168-3659(95)00014-y

Cited by 31 publications

(16 citation statements)

References 8 publications

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“…[3][4][5][6] One of the least complicated approaches to the manufacture of sustained release dosage forms involves the direct compression of blend of drug, retardant material and additives to formulate a tablet in which the drug is embedded in a matrix of the retardant. [7][8][9] Hydrophilic polymers are widely used in the formulation of modified release oral dosage forms. Various synthetic polymers (hydroxyl propyl methyl cellulose, sodium carboxy methyl cellulose, poly methyl methacrylates, etc) and natural materials (xanthan gum, guar gum, chitosan, etc.)…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Ketoprofen Trilayered Matrix Tablet

Navaneetha¹,

Saritha²,

Reddy³

et al. 2017

Int. Res. J. Pharm.

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The aim of the present work is to design and evaluate the controlled release Ketoprofentrilayered matrix tablets, to release the drug for prolonged period of time, which follows zero order kinetics by maintaining a constant drug level in the plasma. Formulations were prepared by using different ratios of polymers like Hydroxy propyl methyl cellulose (K100 &6 cps) and Ethyl cellulose. The FTIR analysis assured compatibility of drug and excipients. Trilayered tablets containing middle drug core layer and either side of core layer, a barrier polymer layers present, prepared by wet granulation method. After formulation development, the trilayered tablets were evaluated for their appearance, hardness, friability, weight variation, disintegration time, assay, in-vitro drug release and stability studies. Core granuleswhich have shown the desired drug release were selected to prepare the trilayered matrix tablets. Based on the evaluation studies FF8 formulation was optimized. FF8 showed in-vitro drug release of 95.8% for 24h which is shown to have better release than marketed preparation hence considered as most promising preparation. Drug release values of optimized formulation (FF8) were subjected to mathematical kinetic modeling, and the correlation coefficient (R 2 ) values drug release follows zero-order (0.994) kinetics and mechanism of dug release is by KorresmayerPeppas model (0.993). FF8 formulation subjected for accelerated stability study for 3 months and the formulation was found to be stable during the study period.

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Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Ketoprofen Trilayered Matrix Tablet

Navaneetha¹,

Saritha²,

Reddy³

et al. 2017

Int. Res. J. Pharm.

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“…With the advancement in development and technology, various techniques such as osmotically driven pumps [2], matrices with controllable swelling [3] diffusion [4,5] or erosion rates [6], non-uniform drug loading profiles [7][8][9], multilayered matrices [10], and therapeutic molecule or protein in a schematic of a pulsatile or staggered fashion are used for formulating sustained release dosage forms. In the 1930s, a new system of sustained release implantable drug delivery system was administered by subcutaneous route was introduced [11].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Implantable Drug Delivery System of Temozolomide by Using Hydrophilic Polymer

Sindhu¹,

Bhavya²,

P³

et al. 2017

Asian J Pharm Clin Res

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Objective: The present research study was carried out to formulate and evaluate the implants of temozolomide using hydrophilic polymer.Methods: Temozolomide implants were formulated using extrusion method with different grades of carbopol. The powdered blend was evaluated for micromeritic properties such as angle of repose, bulk density, tapped density, Carr's index, and Hausner's ratio. The formulated implants were analyzed for drug content uniformity, thickness, weight variation, and short-term stability study. In vitro release study of implants was performed using 0.1N hydrochloric acid, and it is maintained at 37°C±0.5°C. Results:In vitro release study demonstrated that the release rate of temozolomide from the implant matrix was a function of concentration of the polymer. As the concentration of polymer was increased, drug release from the matrix was extended. The release of drug from all implant formulations was found to be uniform and was extended over a period of 12 hrs. The implant formulations were found sterile, uniform in weight and size. The drug content was found to be in the range of 97.2-101.33%. Conclusion:Drug interaction studies revealed that there were no chemical interactions between temozolomide and polymers used in the study. Short-term stability studies of implants revealed that implants were stable, and there were no significant changes in the physical appearance and drug content of the implant formulations. The results of the study demonstrated that implantable drug delivery system of temozolomide can be formulated using hydrophilic polymer.

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“…This leads to drug release rates, which decrease with time. Different approaches have been suggested to overcome this challenge (e.g., Lee 1984aLee ,b, 1986Chang and Himmelstein, 1990;Danckwerts, 1994;Hildgen and McMullen, 1995). Most of them refer to matrix systems [such as multi-layered tablets (Conte et al, 1993;Hariharan et al, 1994;Qiu et al, 1998;Chidambaram et al, 1998)], osmotic pumps, (Malaterre et al, 2009) and/or devices with special geometry, e.g., hemispheres with a central orifice (Hsieh et al, 1983;Narasimhan and Langer, 1997), biconcave tablets (Benkorah and McMulle, 1994), or donut-shaped systems (Kim, 1995).…”

Section: Introductionmentioning

confidence: 99%