A new HLA‐B*35 allele, B*3589, detected in a Malaysian individual

Phipps, Maude E.; Jinam, Timothy A.

doi:10.1111/j.1399-0039.2008.01195.x

Cited by 5 publications

(1 citation statement)

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“…Two new alleles were detected in the HLA‐B and ‐DQB1 loci in two Jehai individuals. The new HLA‐B allele has already been reported and was designated as B*3589 (25). The new DQB1 allele differs by two basepairs from DQB1*050301 in exon 2.…”

Section: Resultsmentioning

confidence: 99%

Molecular analysis of HLA Class I and Class II genes in four indigenous Malaysian populations

et al. 2010

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This is the first report of high-resolution human leukocyte antigen (HLA) typing in four indigenous groups in Malaysia. A total of 99 normal, healthy participants representing the Negrito (Jehai and Kensiu), Proto-Malay (Temuan) and a native group of Borneo (Bidayuh) were typed for HLA-A, -B, -DRB1 and -DQB1 genes using sequence-based typing. Eleven HLA-A, 26 HLA-B, 16 HLA-DRB1 and 14 HLA-DQB1 alleles were detected, including a new allele, HLA-B*3589 in the Jehai. Highly frequent alleles were A*2407, B*1513, B*1801, DRB1*0901, DRB1*1202, DRB1*1502, DQB1*0303 and DQB1*0502. Principal component analysis based on high-resolution HLA-A, -B and -DRB1 allele frequencies showed close affinities among all four groups, including the Negritos, with other Southeast Asian populations. These results showed the scope of HLA diversity in these indigenous minority groups and may prove beneficial for future disease association, anthropological and forensic studies.

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Section: Resultsmentioning

confidence: 99%