2020
DOI: 10.3390/molecules25071479
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A New Hybrid δ-Lactone Induces Apoptosis and Potentiates Anticancer Activity of Taxol in HL-60 Human Leukemia Cells

Abstract: In the search for new drug candidates, researchers turn to natural substances isolated from plants which may be either used directly or may serve as a source for chemical modifications. An interesting strategy in the design of novel anticancer agents is based on the conjugation of two or more biologically active structural motifs into one hybrid compound. In this study, we investigated the anticancer potential of 4-benzyl-5,7-dimethoxy-4-methyl-3-methylidene-3,4-dihydro-2H-chroman-2-one (DL-247), a new hybrid … Show more

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Cited by 4 publications
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“…The second substructure (Figure B) is the lactone structure. Several compounds containing lactone exhibited remarkable in vitro cytotoxic activity as well as apoptosis against non-small cell lung, breast, and leukemia cancer cell lines. , …”
Section: Resultsmentioning
confidence: 99%
“…The second substructure (Figure B) is the lactone structure. Several compounds containing lactone exhibited remarkable in vitro cytotoxic activity as well as apoptosis against non-small cell lung, breast, and leukemia cancer cell lines. , …”
Section: Resultsmentioning
confidence: 99%
“…Apoptosis was detected by Tunnel assay using the APO-DIRECT™ Kit [31] (Catalog no. 6536KK, BD Biosciences Pharmingen).…”
Section: Tunel Assay For Detection Of Apoptosismentioning
confidence: 99%