A new iridoid glycoside and NO production inhibitory activity of compounds isolated from Russelia equisetiformis

Ochi, Madoka; Matsunami, Katsuyoshi; Otsuka, Hideaki; Takeda, Yoshio

doi:10.1007/s11418-011-0569-z

Cited by 10 publications

(4 citation statements)

References 33 publications

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“…It is reported that the plant is traditionally used in Nigeria for the treatment of diabetes, leukemia and pain and inflammation. Scientific studies have revealed analgesic, anti-inflammatory, antimicrobial, free radical scavenging and membrane-stabilising activity [134-136]. Whole organic plant extracts and isolated phenolic compounds exhibited antinociceptive activity in male Swiss mice [134] in both the writhing and tail-flick tests.…”

Section: Iridoid Chemistry and Researched Anti-inflammatory Iridoid-cmentioning

confidence: 99%

“…The isolated compounds, including rehmaglutin B ( 37 ), catalpol ( 15 ), 6- O - cis -p-coumaroylcatalpol, and verminoside ( 25 ) amongst others were assayed for their inhibitory activity towards NO production in vitro using RAW 264.7 cells. The iridoid compounds verminoside (±8%) ( 25 ) and rehmaglutin B (70%) ( 37 ) showed NO inhibitory activity at 100 µM and rehmaglutin B (IC 50 = 52.8±2.0 µM) inhibited NO production more strongly than the control (L-NMMA) [136]. …”

Section: Iridoid Chemistry and Researched Anti-inflammatory Iridoid-cmentioning

confidence: 99%

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Anti-Inflammatory Iridoids of Botanical Origin

Viljoen

Mncwangi²,

Vermaak³

2012

CMC

177

110

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Inflammation is a manifestation of a wide range of disorders which include; arthritis, atherosclerosis, Alzheimer’s disease, inflammatory bowel syndrome, physical injury and infection amongst many others. Common treatment modalities are usually non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, paracetamol, indomethacin and ibuprofen as well as corticosteroids such as prednisone. These however, may be associated with a host of side effects due to non-selectivity for cyclooxygenase (COX) enzymes involved in inflammation and those with selectivity may be highly priced. Thus, there is a continuing search for safe and effective anti-inflammatory molecules from natural sources. Research has confirmed that iridoids exhibit promising anti-inflammatory activity which may be beneficial in the treatment of inflammation. Iridoids are secondary metabolites present in various plants, especially in species belonging to the Apocynaceae, Lamiaceae, Loganiaceae, Rubiaceae, Scrophulariaceae and Verbenaceae families. Many of these ethnobotanicals have an illustrious history of traditional use alluding to their use to treat inflammation. Although iridoids exhibit a wide range of pharmacological activities such as cardiovascular, hepatoprotection, hypoglycaemic, antimutagenic, antispasmodic, anti-tumour, antiviral, immunomodulation and purgative effects this review will acutely focus on their anti-inflammatory properties. The paper aims to present a summary for the most prominent iridoid-containing plants for which anti-inflammatory activity has been demonstrated in vitro and / or in vivo.

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Section: Iridoid Chemistry and Researched Anti-inflammatory Iridoid-cmentioning

confidence: 99%

Section: Iridoid Chemistry and Researched Anti-inflammatory Iridoid-cmentioning

confidence: 99%

Anti-Inflammatory Iridoids of Botanical Origin

Viljoen

Mncwangi²,

Vermaak³

2012

CMC

177

110

View full text Add to dashboard Cite

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“…Vien et al [ 14 ] obtained a different result in LPS-stimulated BV2 microglial cells using the Griess assay, with an IC 50 value of 61.1 µM, which is much higher than the positive control butein (IC 50 = 4.5 µM). In contrast, Ochi et al [ 147 ] obtained a moderate percentage of inhibition of 40% in cell culture supernatants of LPS-stimulated RAW264.7 macrophages at the concentration of 100 µM, whereas the positive control L-NMMA presents an inhibition value of 55% at the same concentration.…”

Section: Biological Activitiesmentioning

confidence: 90%

Leucosceptosides A and B: Two Phenyl-Ethanoid Glycosides with Important Occurrence and Biological Activities

et al. 2022

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In this review paper, the occurrence in the plant kingdom, the chemophenetic value and the biological activities associated with two specific phenyl-ethanoid glycosides, i.e., leucosceptoside A and leucosceptoside B, were reported. This is the first work ever conducted on such a subject. Analysis of the literature data clearly led to three important conclusions: leucosceptoside A is much more common in plants than leucosceptoside B; leucosceptoside A exerts more biological activities than leucosceptoside B even if nothing can be generally concluded about which one is actually the most potent; neither of these compounds can be used as a chemophenetic marker. These three aspects and more are discussed in more depth in this work.

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“…The positive control butetin had much stronger effects (IC50 = 4.5 µM). Lastly, Ochi et al [145] also obtained moderate results in cell culture supernatants of LPS-stimulated RAW264.7 macrophages with a percentage of inhibition of 40%.…”

Section: Anti-inflammatory Activitymentioning

confidence: 94%

Leucosceptosides A and B: Two Phenyl-ethanoid Glycosides with Important Occurrence and Biological Activities

Frezza¹,

Vita²,

Toniolo³

et al. 2022

Preprint

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In this review paper, the occurrence in the plant kingdom and the biological activities associated to two specific phenyl-ethanoid glycosides i.e., leucosceptoside A and leucosceptoside B, were shown and discussed. This is the first work ever done on such subject. Analysis of the literature data clearly indicates that leucosceptoside A is much more common in plants and exerts many more biological activities than leucosceptoside B even if this also presents some important elements. All of this was widely discussed in this paper.

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A new iridoid glycoside and NO production inhibitory activity of compounds isolated from Russelia equisetiformis

Cited by 10 publications

References 33 publications

Anti-Inflammatory Iridoids of Botanical Origin

Anti-Inflammatory Iridoids of Botanical Origin

Leucosceptosides A and B: Two Phenyl-Ethanoid Glycosides with Important Occurrence and Biological Activities

Leucosceptosides A and B: Two Phenyl-ethanoid Glycosides with Important Occurrence and Biological Activities

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