1998
DOI: 10.1006/geno.1998.5222
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A New Isoform of Human Myosin Phosphatase Targeting/Regulatory Subunit (MYPT2): cDNA Cloning, Tissue Expression, and Chromosomal Mapping

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Cited by 78 publications
(74 citation statements)
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“…MYPT3 aligns 99 % with a region of genomic DNA from mouse clone RP23-156P23 and localizes to chromosome 15, between markers at 44.0-45.5 cM, as demonstrated in the present work by radiation hybrid mapping. In contrast, in situ hybridization analysis localizes the 4.8 kb MYPT1 and the 3.8 kb MYPT2 gene to human chromosome 12q15-q21 and 1q32.1 respectively [41,42]. In the present study, we identify the 3.8 kb coding region, comprising 10 exons encoding for a 524-amino-acid sequence with a predicted molecular mass of 57529 Da.…”
Section: Discussionmentioning
confidence: 56%
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“…MYPT3 aligns 99 % with a region of genomic DNA from mouse clone RP23-156P23 and localizes to chromosome 15, between markers at 44.0-45.5 cM, as demonstrated in the present work by radiation hybrid mapping. In contrast, in situ hybridization analysis localizes the 4.8 kb MYPT1 and the 3.8 kb MYPT2 gene to human chromosome 12q15-q21 and 1q32.1 respectively [41,42]. In the present study, we identify the 3.8 kb coding region, comprising 10 exons encoding for a 524-amino-acid sequence with a predicted molecular mass of 57529 Da.…”
Section: Discussionmentioning
confidence: 56%
“…MYPT3 mRNA is widely expressed in various mouse tissues, as well as in 3T3-L1 fibroblasts and differentiated adipocytes. While MYPT3 and MYPT2 are ubiquitously expressed, MYPT1 mRNA is found mainly in heart and brain [41,42]. However, even if found in the same tissue type, it remains to be seen if MYPT3 locates to the same subcellular compartments as MYPT1\2.…”
Section: Discussionmentioning
confidence: 99%
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“…Like the myosin binding subunits of other species, Drosophila Mbs contains multiple N-terminal ankyrin repeats, a conserved motif (RRSTQGVTL) surrounding the key inhibitory threonine site, T 593 , and a C-terminal domain similar to a leucine zipper (Figure 2A; Shimizu et al, 1994;Fujioka et al, 1998;Hartshorne et al, 1998). The first 300 amino acids of Mbs are sufficient for constitutive myosin phosphatase activity (Tanaka et al, 1998;Totsukawa et al, 2000).…”
Section: Loss Of Myosin Binding Subunit Causes the Mutant Eye Phenotypementioning
confidence: 99%
“…Importantly, myosin phosphatase is also expressed in cardiac and skeletal muscle (Fujioka et al 1998;Arimura et al 2001). In cardiomyocytes, overexpression of myosin phosphatase subunits results in the abolition of agonist-induced sarcomere organization, a marker of cardiac hypertrophy (Okamoto et al 2006).…”
Section: Resultsmentioning
confidence: 99%