A new luminescent bio-probe of Europium(III)-complex for sensing some biomolecules and CT-DNA

Azab, Hassan A.; Khairy, Gasser M.; El-Ghany, Nadia Abd; Ahmed, Marwa A.

doi:10.1016/j.jphotochem.2019.01.002

Cited by 8 publications

(13 citation statements)

References 31 publications

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“…The absorption spectra of DOCA in the presence of Eu(III) showed a decrease in the absorbance of the previous three bands with a redshift for the band at 330 nm to 343 nm. In contrast, the bands at 229 and 282 nm remain unchanged, revealing the binding between DOCA and the Eu(III) ion and formation of a complex [31]. The molar absorbance of the probe at 343 nm was calculated to be 8800 ± 150 M −1 cm −1 .…”

Section: Uv-vis Spectroscopymentioning

confidence: 95%

Sensitive Determination of Moxifloxacin HCl in Pharmaceuticals or Human Plasma Using Luminescence or Eye Vision

et al. 2022

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A new probe based on the complex of 1,2 dihydro-2-oxoquinoloine-4-carboxylic acid (DOCA) as a ligand with Europium (III) ion was developed for the quantitation of Moxifloxacin HCl (Moxi.HCl) in pharmaceuticals and human plasma using a luminescence method. The metal to ligand ratio of the complex is 1:2 as determined by a Job plot. The determination of Moxi.HCl is based on static quenching of the luminescence of the probe upon coordination of Moxi.HCl. The negative value for ΔG proves that this reaction is spontaneous. The calibration curve was constructed based on a Stern–Volmer equation and the quantitation range was 0.05–80 µg ml−1. This is low enough to determine the drug in blood plasma, even hours after administration, which is not feasible with the methods published so far. The LOD was 15 ng ml−1. The accuracy of the method was demonstrated by good recoveries of spiking experiments in tablets, ophthalmic eyedrops and human blood plasma, where the mean recovery was 99% with RSDs below 5%. The method was validated by closely matching concentrations of the drug found in all these real samples by HPLC. Additionally, Moxi.HCl can be assessed semi-quantitatively by eye vision upon excitation with a UV lamp at 365 nm by a gradual color shift from red to blue with increasing concentrations of Moxi.HCl.

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Section: Uv-vis Spectroscopymentioning

confidence: 95%

Sensitive Determination of Moxifloxacin HCl in Pharmaceuticals or Human Plasma Using Luminescence or Eye Vision

et al. 2022

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“…These alterations indicated the formation of a complex between the HAZ and Eu(III) ions. 40 The related extinction coefficients of the Eu-(AZ) 2 complex were 3 207 = (63 000 ± 300), 3 246 = (15 000 ± 200), and…”

Section: Interaction Of Eu(iii) With 3-allyl-2hydroxybenzohydrazide (...mentioning

confidence: 98%

Luminescent and time-resolved determination of gemifloxacin mesylate in pharmaceutical formulations and spiked blood plasma samples using a lanthanide complex as a probe

Khairy,

Goda,

Anwar

et al. 2024

Anal. Methods

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“…Increasing the temperature usually causes the dissociation of weakly bound compounds. Therefore, chelation-enhanced luminescence quenching (CHEQ) may give us a simple explanation for the luminescence quenching of the complex [64,65]. Therefore, the malathion was coordinated to the probe through the functional thiophosphoryl group (P=S) or carbonyl group (C=O); this chelation formed a nonluminescent complex, causing a quenched luminescence signal.…”

Section: Mechanism Of Quenchingmentioning

confidence: 99%

New Terbium Complex as a Luminescent Sensor for the Highly Selective Detection of Malathion in Water Samples

Rizk,

Alsaiari,

Alsaiari

et al. 2023

Chemosensors

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A novel ligand, namely, (N’,N’’’-((1E,2E)-1,2-diphenylethane-1,2-diylidene)bis(3-allyl-2-hydroxybenzohydrazide) (H2DBAZ), was designed and synthesized. This ligand demonstrated the ability to successfully interact with Tb(III) ions, resulting in the formation of a chemosensor that exhibited luminescent properties. The novel ligand was produced and subsequently subjected to characterization with several analytical techniques, including mass spectroscopy, elemental analysis, Fourier-transform infrared spectroscopy (FTIR), and proton nuclear magnetic resonance spectroscopy (1H NMR). The postulated chemical structure of the Tb(III)–(DBAZ) complex was assessed utilizing a molar ratio approach. The chemosensor exhibited both selectivity and sensitivity towards malathion when compared to other nine organophosphorus pesticides that were investigated in methanol. The method was based on the phenomenon of luminescence static quenching shown by the complex subsequent to its interaction with the malathion pesticide. A linear Stern–Volmer plot was seen and, subsequently, utilized to generate the calibration curve. The observed linear range spanned from 0.39 to 60 µM, with a strong correlation coefficient of 0.999. Additionally, the limit of detection (LOD) was determined to be 0.118 µM. This methodology was successfully employed to measure the presence of malathion in various water samples. This particular complex exhibited promising potential for application in the development of a chemosensor utilizing the molecularly imprinted polymer approach.

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A new luminescent bio-probe of Europium(III)-complex for sensing some biomolecules and CT-DNA

Cited by 8 publications

References 31 publications

Sensitive Determination of Moxifloxacin HCl in Pharmaceuticals or Human Plasma Using Luminescence or Eye Vision

Sensitive Determination of Moxifloxacin HCl in Pharmaceuticals or Human Plasma Using Luminescence or Eye Vision

Luminescent and time-resolved determination of gemifloxacin mesylate in pharmaceutical formulations and spiked blood plasma samples using a lanthanide complex as a probe

New Terbium Complex as a Luminescent Sensor for the Highly Selective Detection of Malathion in Water Samples

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