A New Mathematical Model for the Optimization of the Mobile Phase Composition in HPTLC and the Comparison With Other Models

Cimpoiu, Claudia; Jäntschi, Lorentz; Hodisan, T.

doi:10.1081/jlc-100101742

Cited by 8 publications

(4 citation statements)

References 13 publications

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“…25 for descriptions). Some of the strategies for solvent optimization are the PRISMA method (37,132), the mixture design approach with the solvation parameter model (25,133), a thermodynamic model (134), the Snyder-Soczewinski model (134), simplex (37), quality factor (37), window diagrams (25), overlapping resolution maps (25), and iterative procedures (25). The PRISMA model, which is a three-dimensional geometrical design that correlates the solvent strength and selectivity of the mobile phase, is the most successful and most widely used.…”

Section: Shermamentioning

confidence: 99%

Basic TLC Techniques, Materials, and Apparatus

Sherma¹

2003

Handbook of Thin-Layer Chromatography

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Section: Shermamentioning

confidence: 99%

Basic TLC Techniques, Materials, and Apparatus

Sherma¹

2003

Handbook of Thin-Layer Chromatography

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“…A variety of methods exist in the literature for the detection and determination of 1,4-benzodiazepines like gas chromatography (GC), , high performance liquid chromatography (HPLC), − high-performance thin-layer chromatography (HPTLC), , high-performance liquid chromatography/electrospray ionization tandem mass spectrometry, liquid chromatography/mass spectrometry, spectrophotometry, , and voltammetry . The acid−base behavior of the 1,4-benzodiazepines has also been investigated for determination of equilibrium constants in heterogeneous systems under different experimental conditions. − …”

Section: Introductionmentioning

confidence: 99%

Automated Potentiometric Titration Method for Determination of pKValues: An Application to Benzodiazepines

Bayes¹,

Narasimham²,

Raut³

et al. 2011

J. Chem. Eng. Data

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The acid-base behavior of benzodiazepines was studied by using a new technique GL-pK a in different ethanolwater [up to 50 % (v/v) ethanol] and methanol-water [up to 50 % (v/v) methanol] mixtures and at different temperatures. The ionic strength was maintained using potassium chloride. The primary goal of this work was to study the effect of different factors like dielectric constant, temperature, and ionic strength on the dissociation constant of benzodiazepines in detail as these are widely used in every day medical practice and forensic and clinical investigations. Potentiometric titrations were performed for determination of the pK values. This technique was found to be convenient, accurate, and easily applicable. The pK values obtained were in good agreement with literature values within experimental error.

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“…Some geometrical or mathematical models were proposed and assessed [ 11 , 12 , 13 , 14 , 15 ]. Moreover, some optimization methods that use neural networks have been introduced [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…A series of experiments were performed and the optimum mobile phases were obtained for different classes of compounds (steroids [ 18 , 19 , 20 ] and benzodiazepines [ 13 , 17 ]). The aim of the present research was to assess through statistical parameters and tests two mathematical models created for optimization of mobile phase in chromatographic separation applied on a set of androstane isomers.…”

Section: Introductionmentioning

confidence: 99%

Statistical Assessment of Solvent Mixture Models Used for Separation of Biological Active Compounds

et al. 2008

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Two mathematical models with seven and six parameters have been created for use as methods for identification of the optimum mobile phase in chromatographic separations. A series of chromatographic response functions were proposed and implemented in order to assess and validate the models. The assessment was performed on a set of androstane isomers. Pearson, Spearman, Kendall tau-a,b,c and Goodman-Kruskal correlation coefficients were used in order to identify and to quantify the link and its nature (quantitative, categorical, semi-quantitative, both quantitative and categorical) between experimental values and the values estimated by the mathematical models. The study revealed that the six parameter model is valid and reliable for five chromatographic response factors (retardation factor, retardation factor ordered ascending by the chromatographic peak, resolution of pairs of compound, resolution matrix of successive chromatographic peaks, and quality factor). Furthermore, the model could be used as an instrument in analysis of the quality of experimental data. The results obtained by applying the model with six parameters for deviations of rank sums suggest that the data of the experiment no. 8 are questionable.

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A New Mathematical Model for the Optimization of the Mobile Phase Composition in HPTLC and the Comparison With Other Models

Cited by 8 publications

References 13 publications

Basic TLC Techniques, Materials, and Apparatus

Basic TLC Techniques, Materials, and Apparatus

Automated Potentiometric Titration Method for Determination of pKValues: An Application to Benzodiazepines

Statistical Assessment of Solvent Mixture Models Used for Separation of Biological Active Compounds

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