2014
DOI: 10.1016/j.aca.2014.05.048
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A new measure of orthogonality for multi-dimensional chromatography

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Cited by 140 publications
(103 citation statements)
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“…44 First, the under-sampling effect was calculated considering the number of fractions effectively transferred from the 1 D to the 2 D. Such an approach, which takes into account the 2 D cycle time ( 2 t C = 1 min), and the average 1 D peak width ( 1 ω = 3 min) was estimated as 1.17:…”
Section: ■ Results and Discussionmentioning
confidence: 99%
“…44 First, the under-sampling effect was calculated considering the number of fractions effectively transferred from the 1 D to the 2 D. Such an approach, which takes into account the 2 D cycle time ( 2 t C = 1 min), and the average 1 D peak width ( 1 ω = 3 min) was estimated as 1.17:…”
Section: ■ Results and Discussionmentioning
confidence: 99%
“…For evaluating the performance of the different approaches, a set of 15 sulphonamides studied in previous work [8,9,12] was considered: (1) sulphacetamide, (2) sulphachloropyridazine, (3) sulphadiazine, (4) sulphadimethoxine, (5) sulphaguanidine, (6) sulphamerazine, (7) sulphamethazine, (8) sulphamethizole, (9) sulphamethoxazole, (10) sulphamonomethoxine, (11) sulphanilamide, (12) sulphapyridine, (13) sulphaquinoxaline, (14) sulphathiazole and (15) sulphisoxazole. The chromatographic behaviour of these compounds was examined with columns of different lengths containing four different stationary phases, supplied by Advanced Chromatography Technologies Ltd. (ACE, Aberdeen, Scotland, UK): phenyl, cyano, C18-HL and C18-AQ.…”
Section: Methodsmentioning
confidence: 99%
“…However, HPLC with a single column still presents challenges in terms of resolution, analysis time and baseline drift in gradient elution, due to the limited chemistry of conventional stationary phases. The combination of retention mechanisms by coupling two or more columns in mono- [4][5][6][7][8][9][10][11][12], or multi-dimensional [13][14][15][16] configurations, is currently the best solution to solve this drawback, which has opened enormously the range of resolutions. It is possible to achieve almost continuous transitions between the selectivity of two or more stationary phases by combining columns.…”
Section: Introductionmentioning
confidence: 99%
“…In other words, these methods are insensitive to the distribution of peaks across the space that they occupy. Other methods, such as the so-called asterisk equations developed by Camenzuli and Schoenmakers (2014), more effectively address the issue of peak distribution, but are a bit less intuitive.…”
Section: Primary Theoretical Guiding Principles 235mentioning
confidence: 99%
“…The principles of these different approaches and their advantages and disadvantages have been discussed at length elsewhere and these details are not repeated here. Readers interested in this topic are referred to a number of reviews and other articles (Camenzuli and Schoenmakers, 2014;Carr et al, 2012;Gilar et al, 2012;Schure and Davis, 2015). Figs.…”
Section: Primary Theoretical Guiding Principles 235mentioning
confidence: 99%