A New Melanin Biosynthesis Inhibitor, Melanoxadin from Fungal Metabolite by Using the Larval Haemolymph of the Silkworm, Bombyx mori.

Secondary metabolites from species of the biocontrol agent Trichoderma

“…Both compounds inhibited melanin formation in the larval hemolymph of the silkworm Bombyx mori. Melanoxazal (70) also showed strong inhibitory activity against mushroom tyrosinase (Hashimoto et al 1995;Takahashi et al 1996).…”

Byelyankacin: A Novel Melanogenesis Inhibitor Produced by Enterobacter sp. B20

“…Accordingly, we have screened a wide range of fermented broths for specific inhibitory effects on melanin production by melanocytes. Previously, we have reported screening program for melanogenesis inhibitors from microorganisms, using the larval haemolymph of the silkworm, Bombyx mori, in which we have reported melanoxadin [9] and melanoxazal [10] from the fermented broth of fungal strains. On the other hand, in the course of our screening for inhibitors of melannogenesis using mushroom tyrosinase and B16-2D2 melanoma cells, we discovered a new inhibitor, which we named byelyankacin (1) (Fig.…”

Muscarine, imidazole, oxazole, thiazole and peptide alkaloids, and other miscellaneous alkaloids

“…It possesses melanin biosynthesis inhibitor properties. 4 An oxazole-indole combination accounts for the structure of almazole C 5, an alkaloid obtained from a red seaweed probably of the genus Haraltiophyllum and belonging to the Delerseriaceae family. Since indole dipeptides 6 and 7 were also isolated from this extract a biogenesis for the almazole alkaloids can be proposed.…”